Results 91 to 100 of about 576,763 (311)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Fault detection of helicopter gearboxes using the multi-valued influence matrix method [PDF]

In this paper we investigate the effectiveness of a pattern classifying fault detection system that is designed to cope with the variability of fault signatures inherent in helicopter gearboxes.
Chin, Hsinyung, Danai, Kourosh, Lewicki, David G.   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Dueling dynamics of low-angle normal fault rupture with splay faulting and off-fault damage. [PDF]

Nat Commun, 2023
Biemiller J, Gabriel AA, Ulrich T.
europepmc   +1 more source

The effects of pre-existing discontinuities on the surface expression of normal faults: insights from wet-clay analogue modeling [PDF]

, 2016
We use wet-clay analogue models to investigate how pre-existing discontinuities (i.e. structures inherited from previous tectonic phases) affect the evolution of a normal fault at the Earth\u2019s surface.
Basili, Roberto, Bonini, Lorenzo, Burrato, Pierfrancesco, Seno, Silvio, Toscani, Giovanni, Valensise, Gianluca   +5 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research on dynamic response characteristics of normal fault footwall working face and rock burst prevention technology under the influence of the gob area. [PDF]

Sci Rep, 2023
Tai L, Li C, Gu S, Yu X, Xu Z, Sun L.
europepmc   +1 more source

Verifying the distributed real-time network protocol RTnet using Uppaal [PDF]

, 2006
RTnet is a distributed real-time network protocol for fully-connected local area networks with a broadcast capability. It supports streaming real-time and non-realtime traffic and on-the-fly addition and removal of network nodes.
Hanssen, Ferdy, Jansen, Pierre G., Mader, Angelika   +2 more
core   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research on the deformation and failure law and control technology of surrounding rock in the dense roadway area in footwall of normal fault

Frontiers in Earth Science
To solve the problem of large deformations and failure of rocks surrounding a dense area at the footwall of a normal fault, we considered the F22 fault in the fourth mining area of Dashucun coal mine in Hebei Province as the research object and conducted
Qing Ma, Qing Ma, Qing Ma, Shangyu Bai, Ruixin Zhang, Xuebin Li, ChengCheng Xie, ChengCheng Xie, Xuesheng Liu   +8 more
doaj   +1 more source