Results 121 to 130 of about 576,763 (311)

The width of fault zones in a brittle-viscous lithosphere: Strike-slip faults [PDF]

A fault zone in an ideal brittle material overlying a very weak substrate could, in principle, consist of a single slip surface. Real fault zones have a finite width consisting of a number of nearly parallel slip surfaces on which deformation is ...
Parmentier, E. M.
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Physical Modeling of a Novel Rigid Bottom Wall to Mitigate the Damage of Shallow Tunnels in Normal Faults

Buildings
Tunnels are threatened by fault deformation. Currently, there is a lack of mitigation strategies for shallow tunnels crossing active faults in overlying soils.
Chaofan Yao, Yulin Liu, Yifei Zhang, Suyuan Liu, Wenbo Yang, Deping Guo   +5 more
doaj   +1 more source

Crustal fault reactivation facilitating lithospheric folding/buckling in the central Indian Ocean

, 1996
High-quality, normal-incidence seismic reflection data confirm that tectonic deformation in the central Indian Ocean occurs at two spatial scales: whole lithosphere folding with wavelengths varying between 100 and 300 km, and compressional reactivation ...
Beekman, F., Bull, Jonathan M., Cloetingh, S., Scrutton, R.A.   +3 more
core   +1 more source

How do normal faults grow?

, 2019
This presentation was given in Stavanger, Norway (19/11/2019) at a FORCE structural geology network meeting, hosted at the Norweigan Petroleum Directorate (NPD): https://www.npd.no/en/force/Previous-events/advanced-structural-geological-approach-to-understand-fault-systems-and-basin-evolution/
Jackson, Christopher, Rotevatn, Atle, Bell, Rebecca E., Pan, Sophie, Tvedt, Anette   +4 more
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Paleoseismology of the southwestern Morelia-Acambay fault system, central Mexico [PDF]

Geofísica Internacional, 2009
Fr The Morelia-Acambay Fault System (MAFS) consists of a sequence of E-W and NNE-SSW trending normal faults within the Trans-Mexican Volcanic Belt.
V. H. Garduño Monroy et al
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Low-angle normal faults-low differential stress at mid crustal levels [PDF]

A simple model for frictional slip on pre-existing faults that considers the local stress state near the fault and the effect of non-hydrostatic fluid pressures predicts that low-angle normal faulting is restricted to areas of the crust characterized by ...
Power, W. L.
core   +1 more source