Results 131 to 140 of about 62,824 (310)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Formation Mechanisms and Petroleum Significance of Complex Normal Fault Networks in the Linbei and Panhe Areas, Bohai Bay Basin, China

Journal of Marine Science and Engineering
Orthorhombic normal fault networks in sedimentary basins and their formation mechanisms are of significant geological importance. Orthorhombic normal fault networks and planar H-shaped normal fault networks (HNF) developed in distinct locations along the
Xueyao Huang, Shuping Chen, Huaibo Zhao, Yujie Zhou   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Corrigendum: Displacement/length scaling relationships for normal faults; a review, critique, and revised compilation

Frontiers in Earth Science, 2023
B. A. Lathrop, C. A-L. Jackson, R. E. Bell, A. Rotevatn   +3 more
doaj   +1 more source

Paleoseismology of the southwestern Morelia-Acambay fault system, central Mexico [PDF]

Geofísica Internacional, 2009
Fr The Morelia-Acambay Fault System (MAFS) consists of a sequence of E-W and NNE-SSW trending normal faults within the Trans-Mexican Volcanic Belt.
V. H. Garduño Monroy et al
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Seismic analysis of the Niger Delta gravitational detachment system [PDF]

, 2011
Ductile deformation of overpressured, fine-grained, argillaceous sediments (“mobile shale”) is commonly invoked to explain the deformation style at the base of thin-skinned, gravitational detachment systems.
MALONEY, DOMINIC,PETER
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

An analytical method for strength verification of buried steel pipelines at normal fault crossings

, 2011
The complex problem of strength verification of a buried steel pipeline crossing the trace of a normal active fault is treated analytically, and a refined methodology for the calculation of the axial and bending pipeline strains is presented. In essence,
G.D. Bouckovalas, Gkesouli, Vasiliki, Kouretzis, George P., Karamitros, DK, Karamitros, Dimitris K., G.P. Kouretzis, Kouretzis, GP, Bouckovalas, GD, V. Gkesouli, Bouckovalas, George D., D.K. Karamitros, Gkesouli, V   +11 more
core   +1 more source