Results 121 to 130 of about 62,824 (310)

Fracture characteristics from two reactivated basement fault zones: examples from Norway and Shetland [PDF]

, 2001
Detailed analyses of fracture attributes developed in basement rocks associated with two, crustal-scale faults, have enabled the characteristics and evolution of the fracture system geometry to be documented quantitatively.
Sleight, Janine Michelle
core  

Effects of healing on the seismogenic potential of carbonate fault rocks: Experiments on samples from the Longmenshan Fault, Sichuan, China [PDF]

, 2015
Fault slip and healing history may crucially affect the fault seismogenic potential in the earthquake nucleation regime. Here we report direct shear friction tests on simulated gouges derived from a carbonate fault breccia, and from a clay/carbonate ...
Christopher J. Spiers, Chen, Jianye, ISES: Frictional behaviour of calcite-rich fault rocks & implications for seismicity in carbonate terrains, Spiers, Christopher J., Verberne, Berend A., Berend A. Verberne, CSC: Wenchuan Earthquake: "high angle, thrust earthquake"- requiring high pore pressure, Experimental rock deformation, Jianye Chen   +8 more
core   +1 more source

Fault kinematics of Sakhalin Island based on geological and seismological data [PDF]

Геосистемы переходных зон
The paper presents a tectonic map of Sakhalin Island showing digitized faults derived from 1:1,000,000 scale tectonic maps and identified by geological surveys (detailed on 1:200,000 and 1:50,000 scale maps).
Pavel A. Kamenev, Vladislav A. Degtyarev, Olga A. Zherdeva, Yury V. Kostrov   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Structural heterogeneity and permeability in faulted eolian sandstone: Implications for subsurface modeling of faults [PDF]

, 2002
We determined the structure and permeability variations of a 4 km-long normal fault by integrating surface mapping with data from five boreholes drilled through the fault (borehole to tens of meters scale).
Shipton, Zoe K., Forster, Craig B., Forster, C.B., Robeson, K.R., Snelgrove, S., Evans, James P., Shipton, Z.K., Snelgrove, Stephen H., Robeson, Kim R., Evans, J.P.   +9 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The structure and composition of exhumed faults, and their implications for seismic processes [PDF]

, 2000
Field studies of faults exhumed from seismogenic depths provide useful data to constrain seismologic models of fault zone processes and properties. Data collected on the San Andreas Fault in the San Gabriel Mountains has shown that large-displacement ...
Robeson, K., Pachell, M.A., Lim, S., Evans, J.P., Shipton, Z.   +4 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source