Results 61 to 70 of about 42,179 (263)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Paleoseismic events and ages revealed by the Lianhuashan trench in the western section of the Tuyouqi of the Daqingshan piedmont fault

地震科学进展
Daqingshan piedmont fault is located in the northern margin of Hetao basin and has been active strongly since the Late Quaternary. Previous researchers had conducted extensive research on the characteristics of paleoseismic in this area, but limited by ...
Yunsheng Yao, Aiguo Wang, Yanxiu Shao, Xingwang Liu, Bo Zhang, Yuanyuan Jia   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Displacement Accumulation and Sampling of Paleoearthquakes on Active Normal Faults of Crete in the Eastern Mediterranean

Geochemistry, Geophysics, Geosystems, 2020
Active normal faults on the Mediterranean island of Crete form prominent limestone scarps together with basin and range topography. These faults mainly strike E‐ESE and N‐NNE in southern and northern Crete, respectively, with fault sets commonly ...
Andrew Nicol, Vasiliki Mouslopoulou, John Begg, Onno Oncken   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

INTERNAL STRUCTURE OF FAULT ZONES: SPATIAL AND TEMPORAL EVOLUTION STUDIES ON CLAY MODELS

Геодинамика и тектонофизика, 2015
Based on results obtained from experiments on clay models, it appeared possible to establish main regularities in the evolution of normal and strike-slip zones which structures are formed heterogeneously in time and space.
Konstantin Zh Seminsky
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Influences of normal fault dislocation on response of surrounding rock and lining system based on discrete-continuous coupling simulation

Yantu gongcheng xuebao, 2020
The seismic damage records show that the destruction of tunnel structure mostly occurs in the fault zone with surrounding rock mass of poor quality and great changes in stratigraphic conditions.
MA Ya-lina 1, 2, CUI Zhen 1, 2, SHENG Qian 1, 2, ZHOU Guang-xin 1, 2, WANG Tian-qiang 3
doaj   +1 more source