Results 121 to 130 of about 18,139,107 (303)
Normal forms and normal theories in conditional rewriting
J. Log. Algebraic Methods Program., 2016 Salvador Lucas, J. Meseguer
semanticscholar +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Reconstruction of normal forms by learning informed observation geometries from data. [PDF]
Proc Natl Acad Sci U S A, 2017 Yair O +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Normal Forms for Nonautonomous Nonlinear Difference Systems Under Nonuniform Dichotomy Spectrum
Journal of Function SpacesIn this paper, the normal forms of nonautonomous nonlinear systems with discrete time are investigated. We first employ the nonuniform kinematic similarity to prove the nonuniform dichotomy spectrum theorem, which is not based on linear integral ...
Ning Song
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Normal forms for singularities of one dimensional holomorphic vector fields
Electronic Journal of Differential Equations, 2004 : We study the normal form of the ordinary differential equation $dot z=f(z)$, $zinmathbb{C}$, in a neighbourhood of a point $pinmathbb{C}$, where $f$ is a one-dimensional holomorphic function in a punctured neighbourhood of $p$.
Antonio Garijo +2 more
doaj
Carleman linearization and normal forms for differential systems with quasi-periodic coefficients. [PDF]
Springerplus, 2016 Chermnykh SV.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source