Results 121 to 130 of about 6,305,486 (301)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Effect of Decomposition Rule Modeling on the Efficiency of Hierarchical Planners
Proceedings of the International Florida Artificial Intelligence Research Society ConferenceHierarchical planning is a widely used approach in automated planning that breaks down complex tasks into manageable subtasks, facilitating more efficient problem-solving.
Roman Bartak +2 more
doaj
Space-Efficient Secret Sharing Based on Matrix Normal Forms
CryptographySecret sharing schemes distribute a secret among participants so that only authorised subsets can reconstruct it. In this paper, we focus on space-efficient secret sharing and show that matrix normal forms can significantly reduce share sizes while ...
Eckhard Pfluegel +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Texas Real Estate Forms Manual: Third Edition, Volume 3
, 2017 Third volume of a manual compiled by professional lawyers in the state of Texas regarding the processes and forms needed for typical real estate transactions.
State Bar of Texas. Real Estate Forms Committee.
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Texas Real Estate Forms Manual: Third Edition, Volume 1
, 2017 First volume of a manual compiled by professional lawyers in the state of Texas regarding the processes and forms needed for typical real estate transactions.
State Bar of Texas. Real Estate Forms Committee.
core
Symmetry, Integrability and Geometry: Methods and Applications, 2009 Cartan's method of moving frames is briefly recalled in the context of immersed curves in the homogeneous space of a Lie group $G$. The contact geometry of curves in low dimensional equi-affine geometry is then made explicit.
Peter J. Vassiliou
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source