Results 51 to 60 of about 20,784,699 (275)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Study of chaos in hamiltonian systems via convergent normal forms

, 1996
We use Moser's normal forms to study chaotic motion in two-degree hamiltonian systems near a saddle point. Besides being convergent, they provide a suitable description of the cylindrical topology of the chaotic flow in that vicinity.
Alfredo M.O. de Almeida, Amol'd, Arnol'd, Arnol'd, Baranger, Berry, Birkhoff, Birkhoff, Churchill, de Matos, de Pinho, Fordy, Gustavson, Hénon, Hénon, Moser, Moser, Ozorio de Almeida, Ozorio de Almeida, Press, Ritter, Werner M. Vieira   +21 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Entanglement on mixed stabilizer states: normal forms and reduction procedures

, 2005
Published ...
Aaronson S Gottesman D, Anders S Briegel H-J, Calsamiglia J Hartmann L Dür W Briegel H-J, Fattal D Cubitt T S Yamamoto Y Bravyi S Chuang I L, Galvão E F, Gottesman D, Gottesman D, Guehne O Toth G Hyllus Ph Briegel H-J, Koenraad M R Audenaert, Linden N Popescu S Schumacher B Westmoreland M, Martin B Plenio, Nielsen M A, Plenio M B Virmani S, Schlingemann D, Schlingemann D, Schlingemann D, Van den Nest M Dehaene J De Moor B   +16 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Greibach normal form transformation, revisited

Information and Computation, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Blum, Norbert, Koch, Robert
openaire   +1 more source

Nonlinear stability analysis of plane Poiseuille flow by normal forms

, 1995
In the subcritical interval of the Reynolds number 4320\leq R\leq R_c\equiv 5772, the Navier--Stokes equations of the two--dimensional plane Poiseuille flow are approximated by a 22--dimensional Galerkin representation formed from eigenfunctions of the ...
A. Rauh, Arneodo, Arnol'd, Bayly, Carr, Eckhaus, Gary, Guckenheimer, Haken, Hassard, Herbert, Herbert, J. Zoller, Landau, Landau, Orszag, Orszag, Pade, Rauh, Schlichting, Sen, Soibelman, Stuart, T. Zachrau, Watson, Wiggins   +25 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source