Results 41 to 50 of about 4,084,972 (304)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Frequency of Patients with Normal Glucose Tolerance or Impaired Glucose Tolerance.

, 2013
Normal Glucose Tolerance: 2h-PG≤140 mg/dl; Impaired Glucose Tolerance: 2h-PG≥140 mg/dl.OSAS, Obstructive sleep apnea syndrome; RLS, Restless legs syndrome; INS, Insomnia; CON, controls.χ2 (3) = 7.95 ...
Thomas Pollmächer (366652), Steffen Birkmann (366646), Marietta Keckeis (366636), Zuzana Lattova (366638), Christoph J. Lauer (366648), Johanna Wilde-Frenz (366651), Thomas C. Wetter (366650), Pierre A. Beitinger (366643), Eszter Maurovich-Horvat (366640)   +8 more
core   +1 more source

International Diabetes Federation guideline for management of postmeal glucose : a review of recommendations [PDF]

, 2008
Diabetes is a significant and growing concern, with over 246 million people around the world living with the disease and another 308 million with impaired glucose tolerance.
Colagiuri S., Ceriello, Antonio, Colagiuri, Stephen   +2 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect [PDF]

, 2011
The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning.
Riby, Leigh, Jonathan K. Foster, Riby, L., Michael A. Smith, Smith, M., van Eekelen, A., van Eekelen, Anke, Foster, Jonathan, J. Anke M. van Eekelen, Smith, Michael, Leigh M. Riby   +10 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

New-onset diabetes after transplantation - Role of oral glucose tolerance test for diagnosis and study of risk factors

Saudi Journal of Kidney Diseases and Transplantation, 2013
To determine the role of the oral glucose tolerance test in the early detection of new-onset diabetes after transplantation (NODAT) and to compare the various risk factors and insulin kinetics in the transplant patients, we studied 41 live-related renal ...
Manisha Sahay, Rakesh K Sahay, Girish Narayan, Anuradha   +3 more
doaj   +1 more source

Maternal variables that differ significantly between normal glucose tolerance and gestational diabetes mellitus pregnancies in univariate analysis.

, 2023
Maternal variables that differ significantly between normal glucose tolerance and gestational diabetes mellitus pregnancies in univariate analysis.
Bernel Ortega-Contreras (9681464), Daniela Mennickent (9681461), Sebastián Gutiérrez-Vega (9681455), Enrique Guzmán-Gutiérrez (295518), Andrés Rodríguez (2213113), Erica Castro (2615470), Juan Araya (14425266)   +6 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source