Results 171 to 180 of about 787,863 (229)

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Autonomic small fiber involvement in painful long COVID: a histological and clinical study. [PDF]

Front Hum Neurosci
Falco P, Galosi E, Litewczuk D, Evangelisti E, Di Stefano G, Arendt-Nielsen L, Truini A, Leone CM.   +7 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Peroxisomal activity drives aggressive bladder cancer phenotypes and reveals erythorbic acid as a potential therapeutic modulator. [PDF]

Front Oncol
Wu Q, Zhou Y, Ou Z, Fu H, Zeng F, Li D, Zheng Z, Wang F.   +7 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO₂ Laser Treatment for Atrophic Acne Scars: A Randomized, Investigator-Blinded, Split-Face, Controlled Trial. [PDF]

J Cosmet Dermatol
Shi Y, Xu S, Zhang W.
europepmc   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Assessment of bronchodilator response using forced oscillation technique in paediatric asthmatic patients from Central India: A cross-sectional study. [PDF]

Lung India
Rathod SB, Sorte SR, Phatak MS, Madhura AD, Vij VA.   +4 more
europepmc   +1 more source

A Histopathological Study of Induced Open Wounds Treated With Urinary Bladder Submucosa Scaffold in Rabbits. [PDF]

Vet Med Int
Alkhilani MA, Hammoodi OT, Tala'a AA, Al-Nuaimy W.   +3 more
europepmc   +1 more source

A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification. [PDF]

Front Cell Dev Biol
Wang W, Cui B, Li H, Zhen Z, Song X, Yuan X, Cui Q, Yuan Q, Liu Y.   +8 more
europepmc   +1 more source