Results 291 to 300 of about 5,621,576 (372)

Sensitivity Analysis in Meta-Analysis: A Tutorial. [PDF]

Cochrane Evid Synth Methods
Aung NM, Jurak I, Mehmood S, Axon E.
europepmc   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Disordered DNA methylation leads to targetable transcriptional plasticity in ATRT. [PDF]

Acta Neuropathol Commun
Tetens AR, Findlay TR, Craig-Schwartz J, Liapodimitri A, Camacho O, Skalitzky KO, Idrizi A, Tryggvadottir R, Lunsford K, Raabe EH, Koldobskiy MA.   +10 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Efficacy of dexmedetomidine in preventing emergence agitation in children undergoing tonsillectomy and/or adenoidectomy: a meta-analysis and systematic review. [PDF]

BMC Anesthesiol
Wang L, Fang S, Cheng L, Liu J, Qin S, Wang Y, Liu Y.   +6 more
europepmc   +1 more source

Effects of Intravenous Laser Irradiation of Blood on Metabolic Markers in Patients With Hyperlipidemia: A Retrospective Pilot Study. [PDF]

In Vivo
Huang CY, Lee CY, Chiang IT, Chang Y, Kung LC, Chen WT, Chang HF, Su LT, Lan TM, Chiu PE, Liu YC.   +10 more
europepmc   +1 more source

Distinct Characteristics of Patients with Gout and an Underweight or Normal Body Mass Index: A Single-Center Retrospective Cross-Sectional Study. [PDF]

Life (Basel)
Ahn SS, Kim JA, Ryu S, Shin Y, Choi SH, Choi KY, Bae K.   +6 more
europepmc   +1 more source

Interaction Between Smoking and Olfactory Function on Frailty: A Population-Based Cross-Sectional Study. [PDF]

Health Sci Rep
Li G, Ye F, Chen K.
europepmc   +1 more source

The impact of hormonal fluctuations and the efficacy of targeted hormonal interventions in improving macular hole outcomes. [PDF]

Front Med (Lausanne)
Ni L, Ma L, Fan M, Zhang L.
europepmc   +1 more source