Results 211 to 220 of about 740,351 (248)

Guidance for data analysis in split-plot designs when parametric assumptions are violated: <i>F</i>-statistic, adjusted <i>F</i>-tests, and bootstrap-<i>F</i>. [PDF]

Front Psychol
Blanca MJ, Alarcón R, Bono R, Arnau J, García-Castro FJ, Vallejo G.   +5 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity. [PDF]

EMBO J
Martí-Mateos Y, Muñoz-Hernández MDM, Gómez de Las Heras MM, Escrig-Larena JI, Cabrera-Alarcón JL, Acín-Pérez R, Calvo E, Jaroszewicz SN, de Prado-Rivas L, Martínez-Jiménez ER, De Andrés-Laguillo M, García-Domínguez E, Gómez-Cabrera MC, Viña J, Benedito R, Efeyan A, Vázquez J, Mittelbrunn M, Jiménez-Gómez MC, Enríquez JA.   +19 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke. [PDF]

Front Pharmacol
Wei C, Zhai CZ, Yue CL, Wang YZ, Cao Y, Yang QW, Zhang ZH, Xu XH.   +7 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Small-sided games as an integrated training strategy: effects on aerobic endurance and passing performance in adolescent soccer players - a randomized controlled trial. [PDF]

BMC Sports Sci Med Rehabil
Seyhan S, Gündüz FC, Açar G, Girginer FG, Soylu Ç, Aslan YE, Bilici MF.   +6 more
europepmc   +1 more source

Linguistic Manoeuvres: Obstetric Violence Camouflages Harm and Loss of Consent From Birth. [PDF]

Med J Aust
Pollock W, Fleming A, Fooladi E, Kloester J, Tremayne A, Zisin Y, Carr B, Davey K, Willey S, Gamble J.   +9 more
europepmc   +1 more source