Results 61 to 70 of about 526,031 (267)

The Social Constructedness of Resilience

open access: yesSocial Sciences, 2015
This essay aims to clarify what it means to de-essentialize the concept of “resilience”. Pre-determinated assumptions regarding its normativity or positive character are to be disproven in order to conceptualize it as an open (social) process; thus to ...
Martin Endress
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Local Linear Regression for Functional Ergodic Data with Missing at Random Responses

open access: yesMathematics
In this article, we develop a novel kernel-based estimation framework for functional regression models in the presence of missing responses, with particular emphasis on the Missing At Random (MAR) mechanism.
Yassine Baghli   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Espaçamento entre plantas de sorgo granífero: produtividade de grãos e qualificação do modelo estatístico Spacing between plants of grains sorghum: grain yield and qualification of the statistical model

open access: yesCiência Rural, 2009
O objetivo deste trabalho foi estudar a regularidade do espaçamento entre plantas de sorgo granífero em relação à produtividade de grãos para a qualificação da análise estatística.
Sidinei José Lopes   +5 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Comment on Hogan and Foster: The future is here

open access: yesInternational Journal of Personality Psychology, 2017
This response to Hogan and Foster’s (2016) rethinking of personality refutes their claim that both neuroticism and personality psychology are meaningless.
Bertus F. Jeronimus, Harriëtte Riese
doaj  

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The two-sided coin – disability, normalcy and social categorization in the New Testament

open access: yesScandinavian Journal of Disability Research, 2015
This article addresses the issue of disability, normalcy and social categorization in relation to the New Testament. It discusses how disabilities ended up in elusive and contradictory categories where a number of various mechanisms and roles coincided ...
Staffan Bengtsson
doaj   +1 more source

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