Results 81 to 90 of about 740,351 (248)
‘No Alarms and No Surprises’: On Normal Abnormalities and an Abnormal Normality
PhilosophiesOn the one hand, disruptive or alienating experiences are quite common, experienced at one time or another by everyone. While they might seem to be exceptional or specifically confined to the elderly, the ill, or the disabled, everyone experiences ...
Maren Wehrle
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comment on Hogan and Foster: The future is here
International Journal of Personality Psychology, 2017 This response to Hogan and Foster’s (2016) rethinking of personality refutes their claim that both neuroticism and personality psychology are meaningless.
Bertus F. Jeronimus, Harriëtte Riese
doaj
The two-sided coin – disability, normalcy and social categorization in the New Testament
Scandinavian Journal of Disability Research, 2015 This article addresses the issue of disability, normalcy and social categorization in relation to the New Testament. It discusses how disabilities ended up in elusive and contradictory categories where a number of various mechanisms and roles coincided ...
Staffan Bengtsson
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Statistical Assumptions of Substantive Analyses across the General Linear Model: A Mini-Review
Frontiers in Psychology, 2012 The validity of inferences drawn from statistical test results depends on how well data meet associated assumptions. Yet, research (e.g., Hoekstra, Kiers, & Johnson, 2012) indicates that such assumptions are rarely reported in literature and that ...
Kim F Nimon
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2009 NormaLity/Normativity brings together essays from a number of different fields that challenge the selfevidence of normality and bring to light its normative dimensions.
core +4 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source