Results 181 to 190 of about 12,123 (304)

A Geometrically Regularized Gradient‐Damage Model With Orthogonality‐Based Energy Split for Dynamic Anisotropic Compression‐Shear Fracture

open access: yesInternational Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT This study proposes a novel geometrically regularized gradient‐damage model for simulating dynamic mixed‐mode fracture in orthotropic materials with tension–compression asymmetry. In this model, a thermodynamic framework is formulated by incorporating damage dissipation into internal energy evolution, from which the constitutive relation and ...
Hui Li, Shanyong Wang
wiley   +1 more source

Reconsidering Volume‐Based Drug Procurement Policy: The Consequences of Manufacturers' Optimal Production Planning and Breach Strategies

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT This paper examines the impacts of Volume‐Based Procurement (VBP) policies on pharmaceutical supply chains, with a focus on the strategic behaviors of manufacturers. VBP aims to reduce costs and stabilize supplies by centralizing procurement through competition based on volumes and prices.
Nani Zhou, Tong Wang, Guohua Wan
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Optimal Designs and Inspection Time Decisions for Gamma Accelerated Degradation Tests

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT This study analytically derives optimal designs for gamma accelerated degradation tests while incorporating inspection time as a design variable under both D‐ and V‐optimality criteria. Under D‐optimality, we prove that the optimal design allocates test units exclusively to the lowest and highest stress levels and adopts the longest inspection
Hung‐Ping Tung, I‐Chen Lee
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

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