Results 81 to 90 of about 330,644 (260)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A machine learning analysis for hybrid nanofluid flow between two co-axial cylinders

Scientific Reports
This study investigates steady, incompressible, heat transfer and axisymmetric flow in a hybrid nanofluid, magnetite and multi-walled carbon nanotubes dispersed in water, confined in the annular space between two coaxial cylinders (outer radius ...
Kiran Batool, Sadia Shakir, Saima Zainab, Hijaz Ahmad, Neissrien Alhubieshi, Mohamed R. Eid, Assmaa Abd-Elmonem, Abdulrazak H. Almaliki   +7 more
doaj   +1 more source

Effectiveness of pharmacotherapies for diabetes on nicotine, food, and water intake in insulin-resistant rats

Advances in Drug and Alcohol Research
The intersectionality between diabetes medications and nicotine consumption was assessed in female and male rats. Briefly, the rats were fed a high-fat diet (HFD) or regular diet (RD) for 4 weeks.
Sebastian Ortegon, Priscilla Giner, Bryan Cruz, Luis M. Carcoba, Benjamin Clapp, Deborah J. Clegg, Laura E. O’Dell   +6 more
doaj   +1 more source

Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. [PDF]

, 2019
BackgroundCharacterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the subject of extensive optimization,
Chen, Irene A, Deacon, John M, Kim, Colin Y, Verbanic, Samuel   +3 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Changes in Vegetation Growth Dynamics and Relations with Climate over China’s Landmass from 1982 to 2011

Remote Sensing, 2014
Understanding how the dynamics of vegetation growth respond to climate change at different temporal and spatial scales is critical to projecting future ecosystem dynamics and the adaptation of ecosystems to global change.
Guang Xu, Huifang Zhang, Baozhang Chen, Hairong Zhang, John L. Innes, Guangyu Wang, Jianwu Yan, Yonghong Zheng, Zaichun Zhu, Ranga B. Myneni   +9 more
doaj   +1 more source

Power series expansion and decreasing property related to normalized remainders of power series expansion of sine

Filomat
In the paper, with the aid of a derivative formula for the ratio of two differentiable functions, in view of a monotonicity rule for the ratio of two differentiable functions, in terms of the Hessenberg determinants, the authors present a Maclaurin power series expansion of the logarithm of the normalized remainder of the Maclaurin power series ...
Fei Wang, Feng Qi
openaire   +1 more source

Arbitrarily small perturbations of Dirichlet Laplacians are quantum unique ergodic [PDF]

, 2017
Given an Euclidean domain with very mild regularity properties, we prove that there exist perturbations of the Dirichlet Laplacian of the form $-(I+S_\epsilon)\Delta$ with $\|S_\epsilon\|_{L^2\to L^2}\leq \epsilon$ whose high energy eigenfunctions are ...
Chatterjee, Sourav, Galkowski, Jeffrey
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source