Results 91 to 100 of about 294,135 (314)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Normal Solutions [PDF]

Botanical Gazette, 1901
Louis Kahlenberg, James B. Dandeno
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Normalized solutions for the double-phase problem with nonlocal reaction

Advances in Nonlinear Analysis
In this article, we consider the double-phase problem with nonlocal reaction. For the autonomous case, we introduce the methods of the Pohozaev manifold, Hardy-Littlewood Sobolev subcritical approximation, adding the mass term to prove the existence and ...
Cai Li, Zhang Fubao
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Solutions with prescribed mass for the Sobolev critical Schrödinger–Poisson system with p-Laplacian

Bulletin of Mathematical Sciences
In this paper, we are concerned with the existence and properties of ground states for the quasilinear Schrödinger–Poisson system with combined critical nonlinearities −Δpu+γϕ|u|p−2u=λ|u|p−2u+μ|u|q−2u+|u|p∗−2uin ℝ3,−Δϕ=|u|pin ℝ3, having prescribed mass ...
Kai Liu, Xiaoming He
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Multiplicity of normalized solutions for nonlinear Choquard equations

Advanced Nonlinear Studies
In this paper, we consider the following nonlinear Choquard equation with prescribed L 2-norm: −Δu+λu=Iα∗F(u)f(u) in RN,∫RN|u|2dx=a>0,u∈H1(RN), $\begin{cases}-{\Delta}u+\lambda u=\left({I}_{\alpha }\ast F\left(u\right)\right)f\left(u\right) \,\text{in}\,
Long Chun-Fei, Deng Chonghao, Li Gui-Dong, Tang Chun-Lei   +3 more
doaj   +1 more source

Non-singular solutions to the normalized Ricci flow equation [PDF]

, 2006
Fuquan Fang, Yuguang Zhang, Zhenlei Zhang   +2 more
openalex   +1 more source