Results 101 to 110 of about 3,355,287 (250)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Normalized solutions for the Kirchhoff equation with combined nonlinearities in ℝ4

Advances in Nonlinear Analysis
In this article, we study the following Kirchhoff equation with combined nonlinearities: −a+b∫R4∣∇u∣2dxΔu+λu=μ∣u∣q−2u+∣u∣2u,inR4,∫R4∣u∣2dx=c2,\left\{\begin{array}{l}-\left(a+b\mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{4}}{| \nabla u| }^{2}{\rm ...
Qiu Xin, Ou Zeng-Qi, Tang Chun-Lei, Lv Ying   +3 more
doaj   +1 more source

Concentration of solutions with prescribed mass for -Laplacian equations with nonlocal reaction

Bulletin of Mathematical Sciences
In this paper, we consider the following [Formula: see text]-Laplacian equation with nonlocal reaction L(u)+V(𝜖x)(|u|p−2u+|u|q−2u)=λ|u|p−2u+(Iα∗|u|pα)|u|pα−2u+(Iα∗F(u))f(u)in ℝN,∫ℝN|u|pdx=cpin ℝN, where [Formula: see text], [Formula: see text] [Formula ...
Li Cai, Peng Ji, Peng Jin
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Existence of normalized solutions to Kirchhoff-Boussinesq equations in the subcritical and supercritical regime

Electronic Journal of Differential Equations
In this article we study the existence of normalized solutions to the Kirchhoff-Boussinesq equation under the mass constraint $\|u\|_{2}=c$. In the $L^{2}$-subcritical regime, we apply Ekeland's variational principle and concentration compactness method ...
Chunling Tao, Lintao Liu, Kaimin Teng
doaj  

Normalized solutions of critical Schrödinger system involving fractional p-Laplacian

Bulletin of Mathematical Sciences
In this paper, we study the normalized solutions of the following critical Schrödinger system involving fractional p-Laplacian: (−Δ)psu+𝒱(𝜀x)|u|p−2u=λ1|u|p−2u+μ1|u|𝔭1−2u+βr1|u|r1−2u|v|r2in ℝN,(−Δ)psv+𝒲(𝜀x)|v|p−2v=λ2|v|p−2v+μ2|v|𝔭2−2v+βr2|u|r1|v|r2−2vin ...
Yuxuan Tong, Xiaojun Chang, Sihua Liang
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Theoretical Regularity Properties of the Normalized Quadratic Consumer Demand Model [PDF]

We conduct a Monte Carlo study of the global regularity properties of the Normalized Quadratic model. We particularly investigate monotonicity violations, as well as the performance of methods of locally and globally imposing curvature.
William Barnett, Ikuyasu Usui
core  

Normalized homoclinic solutions of discrete nonlocal double phase problems

Bulletin of Mathematical Sciences
The aim of this paper is to discuss the existence of normalized solutions to the following nonlocal double phase problems driving by the discrete fractional Laplacian: ( − Δ𝔻)pαu(k) + μ(−Δ 𝔻)qβu(k) + ω(k)|u(k)|p−2u(k) = λ|u(k)|q−2u(k) + h(k)|u(k)|r−2u(k)
Mingqi Xiang, Yunfeng Ma, Miaomiao Yang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source