Results 121 to 130 of about 3,355,287 (250)

Solutions with prescribed mass for the Sobolev critical Schrödinger–Poisson system with p-Laplacian

Bulletin of Mathematical Sciences
In this paper, we are concerned with the existence and properties of ground states for the quasilinear Schrödinger–Poisson system with combined critical nonlinearities −Δpu+γϕ|u|p−2u=λ|u|p−2u+μ|u|q−2u+|u|p∗−2uin ℝ3,−Δϕ=|u|pin ℝ3, having prescribed mass ...
Kai Liu, Xiaoming He
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Normalized solutions to Kirchhoff type equations with a critical growth nonlinearity [PDF]

In this paper, we are concerned with normalized solutions of the Kirchhoff type equation \begin{equation*} -M\left(\int_{\R^N}|\nabla u|^2\mathrm{d} x\right)Δu = λu +f(u) \ \ \mathrm{in} \ \ \mathbb{R}^N \end{equation*} with $u \in S_c:=\left\{u \in H ...
Zhang, Jian, Zhang, Jianjun, Zhong, Xuexiu   +2 more
core   +1 more source

Normalized solutions to a class of (2, q)-Laplacian equations

Advanced Nonlinear Studies
This paper is concerned with the existence of normalized solutions to a class of (2, q)-Laplacian equations in all the possible cases with respect to the mass critical exponents 2(1 + 2/N), q(1 + 2/N).
Baldelli Laura, Yang Tao
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Infinitely many normalized solutions for a quasilinear Schrodinger equation

, 2023
In this paper, we are concerned with a quasilinear Schrodinger equation with well-known Berestycki--Lions nonliearity.
Yang, Xianyong, Zhao, Fukun
core  

Blow-up solutions to the Hartree-Fock type Schrödinger equation with the critical rotational speed

Advances in Nonlinear Analysis
In this article, we are concerned with the existence, non-existence, and blow-up behavior of normalized ground state solutions for the mass critical Hartree-Fock type Schrödinger equation with rotation i∂tu=−Δu+2V(x)u+2ΩLzu−λu−bu∫RN∣u(y)∣2∣x−y∣2dy,(t,x ...
Tu Yuanyuan, Wang Jun
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Normalized solutions to Born-Infeld and quasilinear problems

, 2023
The paper concerns the existence of normalized solutions to a large class of quasilinear problems, including the well-known Born-Infeld operator. In the mass subcritical cases, we study a global minimization problem and obtain a ground state solution for
Baldelli, Laura, Pomponio, Alessio, Mederski, Jarosław   +2 more
core