Results 141 to 150 of about 1,045,959 (290)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Normalized solutions of Schrödinger equations involving Moser-Trudinger critical growth

Advances in Nonlinear Analysis
In this article, we are concerned with the nonlinear Schrödinger equation −Δu+λu=μ∣u∣p−2u+f(u),inR2,-\Delta u+\lambda u=\mu {| u| }^{p-2}u+f\left(u),\hspace{1em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{2}, having prescribed ...
Li Gui-Dong, Zhang Jianjun
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Existence of normalized solutions for Schrödinger systems with linear and nonlinear couplings

Boundary Value Problems
In this paper we study the nonlinear Bose–Einstein condensates Schrödinger system { − Δ u 1 − λ 1 u 1 = μ 1 u 1 3 + β u 1 u 2 2 + κ ( x ) u 2 in  R 3 , − Δ u 2 − λ 2 u 2 = μ 2 u 2 3 + β u 1 2 u 2 + κ ( x ) u 1 in  R 3 , ∫ R 3 u 1 2 = a 1 2 , ∫ R 3 u 2 2 =
Zhaoyang Yun, Zhitao Zhang
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Existence of solutions to a normalized F-infinity Laplacian equation

Electronic Journal of Differential Equations, 2014
In this article, for a continuous function F that is twice differentiable at a point $x_0$, we define the normalized F-infinity Laplacian $\Delta_{F; \infty}^N$ which is a generalization of the usual normalized infinity Laplacian. Then for a bounded
Hua Wang, Yijun He
doaj  

Normalized Solutions to Schrödinger Systems with Potentials

Bulletin of the Iranian Mathematical Society
In this paper, we study the normalized solutions of the Schrödinger system with trapping potentials \begin{equation}\label{eq:diricichlet} \begin{cases} -Δu_1+V_1(x)u_1-λ_1 u_1=μ_1 u_1^3+βu_1u_2^{2}+κu_2~\hbox{in}~ \mathbb{R}^3,\\ -Δu_2+V_2(x)u_2-λ_2 u_2=μ_2 u_2^3+βu_1^2u_2+κu_1~\hbox{in}~ \mathbb{R}^3, u_1\in H^1(\mathbb{R}^3), u_2\in H^1(\mathbb{R ...
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source