Results 151 to 160 of about 320,316 (300)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Normalized ground state solutions for Kirchhoff equation with subcritical or critical perturbation

Electronic Journal of Differential Equations
This article concerns the Kirchhoff equation with subcritical or critical perturbation. We establish the existence of normalized ground state solutions by using Pohozaev manifold and subcritical approximation methods.
Zian Fan
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Normalized solutions of Schrödinger equations involving Moser-Trudinger critical growth

Advances in Nonlinear Analysis
In this article, we are concerned with the nonlinear Schrödinger equation −Δu+λu=μ∣u∣p−2u+f(u),inR2,-\Delta u+\lambda u=\mu {| u| }^{p-2}u+f\left(u),\hspace{1em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{2}, having prescribed ...
Li Gui-Dong, Zhang Jianjun
doaj   +1 more source

Multiple Normalized Solutions to a Choquard Equation Involving Fractional p-Laplacian in ℝ^N

In this paper, we study the existence of multiple normalized solutions for a Choquard equation involving fractional p-Laplacian in RN. With the help of variational methods, minimization techniques, and the Lusternik–Schnirelmann category, the existence ...
Xin Zhang, Sihua Liang
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

SOLUTIONS OF GASES IN NORMAL LIQUIDS [PDF]

Proceedings of the National Academy of Sciences, 1967
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Existence of normalized solutions for Schrödinger systems with linear and nonlinear couplings

Boundary Value Problems
In this paper we study the nonlinear Bose–Einstein condensates Schrödinger system { − Δ u 1 − λ 1 u 1 = μ 1 u 1 3 + β u 1 u 2 2 + κ ( x ) u 2 in  R 3 , − Δ u 2 − λ 2 u 2 = μ 2 u 2 3 + β u 1 2 u 2 + κ ( x ) u 1 in  R 3 , ∫ R 3 u 1 2 = a 1 2 , ∫ R 3 u 2 2 =
Zhaoyang Yun, Zhitao Zhang
doaj   +1 more source

Normalized solutions to Schrödinger systems with critical nonlinearities

We consider a system of coupled Schrödinger equations involving critical exponent given by − + 1 = ||−2 + 2 + ||−2|| in R, − + 2 = ||−2 + 2 + || ||−2 in R.
Winkert, Patrick, He, Xiaoming, Meng, Yuxi   +2 more
core   +1 more source