Results 171 to 180 of about 3,355,287 (250)

Development and Validation of an LC-MS/MS Method for the Quantification of HY-078020 in Human Plasma Using Liquid-Liquid Extraction and Its Application to Human Pharmacokinetic Study. [PDF]

Biomed Chromatogr
Wang Y, Zhang M, Cui Y, Shao L, Meng L, Chen M, An M, Shen Z, Chu Z.   +8 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Indocyanine green excitation-emission matrix characterization: excitation-dependent emission shifts and application-specific spectra. [PDF]

J Biomed Opt
Ruiz AJ, Lyon SA, LaRochelle EPM, Samkoe KS.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Normalized solutions for fractional Schrodinger-Choquard systems with Sobolev critical coupled nonlinearity

Electronic Journal of Differential Equations
We study the existence of normalized solutions for a system of fractional Schrodinger-Choquard with Sobolev critical coupling term. We obtain the existence of the positive normalized ground state solution, and in a special case we obtain a mountain ...
Zilin Chen, Yang Yang
doaj  

A Cascaded Neural Network for Robust Phase-Only Beamforming Under Covariance Matrix Mismatch. [PDF]

Sensors (Basel)
Zhao Z, Yu Z, Li Y, Yang Y, Wang Z, Liu Q.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Steady Vortex Sheets in Presence of Surface Tension. [PDF]

J Math Fluid Mech
Murgante F, Roulley E, Scrobogna S.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

World happiness report: Año 2012 [PDF]

, 2012
Sustainable Development Solutions Network
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