Results 51 to 60 of about 294,135 (314)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Infinitely many free or prescribed mass solutions for fractional Hartree equations and Pohozaev identities

Advanced Nonlinear Studies
In this paper we study the following nonlinear fractional Hartree (or Choquard-Pekar) equation (−Δ)su+μu=(Iα*F(u))F′(u) inRN, ${\left(-{\Delta}\right)}^{s}u+\mu u=\left({I}_{\alpha }{\ast}F\left(u\right)\right){F}^{\prime }\left(u\right)\quad \text{in} {\
Cingolani Silvia, Gallo Marco, Tanaka Kazunaga   +2 more
doaj   +1 more source

Normalized Solutions to Kirchhoff Equation with Nonnegative Potential [PDF]

, 2023
Shuai Mo, Shiwang Ma
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

A Revisit of the Normalized Eight-Point Algorithm and A Self-Supervised Deep Solution [PDF]

, 2023
Bin Fan, Yuchao Dai, Yongduek Seo, Mingyi He   +3 more
openalex   +1 more source

A Hollerith Technique for the Solution of Normal Equations

Journal of the American Statistical Association, 1953
IN THlE critical study of the results of large-scale sample surveys it is frequently necessary to consider data classified in several different ways, and to attempt to disentangle the effects of the various classifications which will usually not be orthogonal to one another.
Healy, M. J. R., Dyke, G. V.
openaire   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Multiple normalized solutions for Choquard equation involving the biharmonic operator and competing potentials in

Bulletin of Mathematical Sciences
This paper is concerned with the existence of multiple normalized solutions for a class of Choquard equation involving the biharmonic operator and competing potentials in [Formula: see text]: Δ2u+V(𝜀x)u=λu+G(𝜀x)(Iμ∗F(u))f(u)in ℝN,∫ℝN|u|2dx=c2, where ...
Shuaishuai Liang, Jiaying Ma, Shaoyun Shi, Yueqiang Song   +3 more
doaj   +1 more source