Results 51 to 60 of about 299,484 (312)

Multiple normalized solutions to the nonlinear Schrödinger–Poisson system with the $L^2$-subcritical growth

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we study the existence of multiple normalized solutions to the following Schrödinger–Poisson system with general nonlinearities: \begin{equation*} \begin{cases} -\varepsilon^2\Delta u+V(x)u+\phi u=f(u)+\lambda u & \hbox{in $\mathbb{R}
Siwei Wei, Kaimin Teng
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Existence and non-degeneracy of the normalized spike solutions to the fractional Schrödinger equations

Advances in Nonlinear Analysis
The present study investigates the existence and non-degeneracy of normalized solutions for the following fractional Schrödinger equation: (−Δ)su+V(x)u=aup+μu,x∈RN,u∈Hs(RN){\left(-\Delta )}^{s}u+V\left(x)u=a{u}^{p}+\mu u,\hspace{1.0em}x\in {{\mathbb{R}}}^
Guo Qing, Zhang Yuhang
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

QUASI–PERIODIC RESPONSE SOLUTIONS AT NORMAL–INTERNAL RESONANCES [PDF]

EQUADIFF 2003, 2005
In the conservative dynamics of certain quasi-periodically forced oscillators, normal-internal resonances are considered in a bifurcational setting. The unforced system is a one degree of freedom oscillator, under forcing the system becomes a skew-product flow with a quasi-periodic motion on an $n$-dimensional torus as driving ...
Broer, H. W., Hanssmann, Heinz, Jorba, Angel, Villanueva Castelltort, Jordi, Wagener, Florian   +4 more
openaire   +4 more sources

Infinitely many free or prescribed mass solutions for fractional Hartree equations and Pohozaev identities

Advanced Nonlinear Studies
In this paper we study the following nonlinear fractional Hartree (or Choquard-Pekar) equation (−Δ)su+μu=(Iα*F(u))F′(u) inRN, ${\left(-{\Delta}\right)}^{s}u+\mu u=\left({I}_{\alpha }{\ast}F\left(u\right)\right){F}^{\prime }\left(u\right)\quad \text{in} {\
Cingolani Silvia, Gallo Marco, Tanaka Kazunaga   +2 more
doaj   +1 more source

Existence of normalized solutions for the coupled elliptic system with quadratic nonlinearity

Advanced Nonlinear Studies, 2022
In the present paper, we study the existence of the normalized solutions for the following coupled elliptic system with quadratic nonlinearity −Δu−λ1u=μ1∣u∣u+βuvinRN,−Δv−λ2v=μ2∣v∣v+β2u2inRN,\left\{\begin{array}{ll}-\Delta u-{\lambda }_{1}u={\mu }_{1}| u|
Wang Jun, Wang Xuan, Wei Song
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Normalized solutions for a fractional coupled critical Hartree system

Electronic Journal of Qualitative Theory of Differential Equations
We consider the existence of normalized solutions for a fractional coupled Hartree system, with the upper critical exponent in the sense of the Hardy-Littelwood-Sobolev inequality.
Shengbing Deng, Wenshan Luo
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source