Results 61 to 70 of about 1,045,959 (290)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

QUASI–PERIODIC RESPONSE SOLUTIONS AT NORMAL–INTERNAL RESONANCES [PDF]

open access: yesEQUADIFF 2003, 2005
In the conservative dynamics of certain quasi-periodically forced oscillators, normal-internal resonances are considered in a bifurcational setting. The unforced system is a one degree of freedom oscillator, under forcing the system becomes a skew-product flow with a quasi-periodic motion on an $n$-dimensional torus as driving ...
Broer, H. W.   +4 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

One Parameter Scaling Theory for Stationary States of Disordered Nonlinear Systems

open access: yes, 2010
We show, using detailed numerical analysis and theoretical arguments, that the normalized participation number of the stationary solutions of disordered nonlinear lattices obeys a one-parameter scaling law. Our approach opens a new way to investigate the
Bodyfelt, Joshua D.   +2 more
core   +1 more source

Normalized solutions to nonautonomous Kirchhoff equation

open access: yesCommunications in Analysis and Mechanics
<p>In this paper, we studied the existence of normalized solutions to the following Kirchhoff equation with a perturbation:</p><p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ \left\{ \begin{aligned} &amp;-\left(a+b\int _{\mathbb{R}^{N}}\left | \nabla u \right|^{2} dx\right)\Delta u+\lambda u =
Xin Qiu, Zeng Qi Ou, Ying Lv
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Normalized solutions for Sobolev critical fractional Schrödinger equation

open access: yesAdvances in Nonlinear Analysis
In the present study, we investigate the existence of the normalized solutions to Sobolev critical fractional Schrödinger equation: (−Δ)su+λu=f(u)+∣u∣2s*−2u,inRN,(Pm)∫RN∣u∣2dx=m2,\hspace{14em}\left\{\begin{array}{ll}{\left(-\Delta )}^{s}u+\lambda u=f ...
Li Quanqing   +3 more
doaj   +1 more source

Normalized General Relativity: Non-closed Universe and Zero Cosmological Constant

open access: yes, 2014
We discuss the cosmological constant problem, at the minisuperspace level, within the framework of the so-called normalized general relativity (NGR). We prove that the Universe cannot be closed, and reassure that the accompanying cosmological constant ...
Davidson, Aharon, Rubin, Shimon
core   +1 more source

Normal solutions of linear programs [PDF]

open access: yes, 1984
The author introduces the definition of normal solution to a linear program, which is an exact solution with some least norm property if the linear program is solvable, otherwise an approximate solution with some least norm property also. By considering normal solutions we are led to (i) iterative successive overrelaxation (SOR) methods capable of ...
openaire   +2 more sources

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