Results 61 to 70 of about 3,355,287 (250)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Normalized solutions of fractional Kirchhoff equations: the defocusing case [PDF]
In this article, we focus on the normalized solutions to the fractional Kirchhoff equations with subcritical nonlinearities in the defocusing case. By applying distinct suppositions to the coefficients of nonlinearities, namely \(q < p\), we prove ...
Zhang, Tianqing, Guo, Zhenyu
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
, 2006 "February 1, 2006."; "Pursuant to Public Act 05-280, Sec. 35, The Department of Mental Retardation contracted with Solutions Consulting Group, LLC of Maine for a unit cost study for the Birth-To-Three Early Intervention Program ..."--Letter of ...
Solutions Consulting Group.
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Bulletin of Mathematical SciencesThis paper is concerned with the existence of multiple normalized solutions for a class of Choquard equation involving the biharmonic operator and competing potentials in [Formula: see text]: Δ2u+V(𝜀x)u=λu+G(𝜀x)(Iμ∗F(u))f(u)in ℝN,∫ℝN|u|2dx=c2, where ...
Shuaishuai Liang +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Geode-solutions/OpenGeode: v5.4.3
, 2020 Open source framework for representing and manipulating geometric ...
Geode-solutions, SAS
core +1 more source