Results 51 to 60 of about 3,355,287 (250)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multiple normalized solutions to the nonlinear Schrödinger–Poisson system with the $L^2$-subcritical growth

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we study the existence of multiple normalized solutions to the following Schrödinger–Poisson system with general nonlinearities: \begin{equation*} \begin{cases} -\varepsilon^2\Delta u+V(x)u+\phi u=f(u)+\lambda u & \hbox{in $\mathbb{R}
Siwei Wei, Kaimin Teng
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Existence and non-degeneracy of the normalized spike solutions to the fractional Schrödinger equations

Advances in Nonlinear Analysis
The present study investigates the existence and non-degeneracy of normalized solutions for the following fractional Schrödinger equation: (−Δ)su+V(x)u=aup+μu,x∈RN,u∈Hs(RN){\left(-\Delta )}^{s}u+V\left(x)u=a{u}^{p}+\mu u,\hspace{1.0em}x\in {{\mathbb{R}}}^
Guo Qing, Zhang Yuhang
doaj   +1 more source

Normalized Solution for the Fractional Kirchhoff System with Hardy Nonlinearities

Axioms
In this paper, we consider the existence of normalized solutions for the fractional Kirchhoff system with Hardy critical nonlinearities. The problem combines the challenges of nonlocal operators, singular critical effects, and a variational framework ...
Yufei Wang, Yang Yang
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Intercriteria analysis over normalized data

, 2016
The possibility to apply the intercriteria analysis over normalized data is discussed.
Atanassova, V., Mitkova, M., Sotirov, S., Atanassov, K.T., Stratiev, D., Chountas, P., Sotirova, E.   +6 more
core   +1 more source

Infinitely many free or prescribed mass solutions for fractional Hartree equations and Pohozaev identities

Advanced Nonlinear Studies
In this paper we study the following nonlinear fractional Hartree (or Choquard-Pekar) equation (−Δ)su+μu=(Iα*F(u))F′(u) inRN, ${\left(-{\Delta}\right)}^{s}u+\mu u=\left({I}_{\alpha }{\ast}F\left(u\right)\right){F}^{\prime }\left(u\right)\quad \text{in} {\
Cingolani Silvia, Gallo Marco, Tanaka Kazunaga   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Existence of normalized solutions for the coupled elliptic system with quadratic nonlinearity

Advanced Nonlinear Studies, 2022
In the present paper, we study the existence of the normalized solutions for the following coupled elliptic system with quadratic nonlinearity −Δu−λ1u=μ1∣u∣u+βuvinRN,−Δv−λ2v=μ2∣v∣v+β2u2inRN,\left\{\begin{array}{ll}-\Delta u-{\lambda }_{1}u={\mu }_{1}| u|
Wang Jun, Wang Xuan, Wei Song
doaj   +1 more source