Results 61 to 70 of about 299,484 (312)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Normal solutions of linear programs [PDF]

open access: yes, 1984
The author introduces the definition of normal solution to a linear program, which is an exact solution with some least norm property if the linear program is solvable, otherwise an approximate solution with some least norm property also. By considering normal solutions we are led to (i) iterative successive overrelaxation (SOR) methods capable of ...
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Normalized solutions for quasilinear (p, q)-equations

open access: yesRevista de la Real Academia de Ciencias Exactas, Físicas y Naturales. Serie A. Matemáticas
Abstract In this paper, we study the following quasilinear (p, q)-equation $$\begin{aligned} -\Delta _p u-u\Delta _q u^2+\lambda |u|^{p-2}u=\mu |u|^{l-2}u+|u|^{m-2}u,\quad \text {in}\;{\mathbb {R}}^N, \end{aligned}$$
Li Cai, Vicenţiu D. Rădulescu
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Normal versus Decinormal Salt Solution. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1901
Afton, Ind. Ter., June 20, 1901. To the Editor: —InThe Journalof June 15 is a communication from Dr. C. S. Minnich on normal salt solution; he concludes that the solution meant is the "decinormal," not "normal." "Normal" means "the rule," the general average; if a man, a horse, or a cow has the normal number of teeth, it has the number which is the ...
openaire   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Normal solutions of the Beltrami equation, II

open access: yesJournal of Mathematical Analysis and Applications, 1990
For part I see the authors in ibid. 125, 247-257 (1987; Zbl 0625.30020). Let \(\mu\) be a complex function defined on the unit disk with \(| \mu |
Cima, J.A, Derrick, W.R
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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