Results 61 to 70 of about 1,014,924 (284)

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Normalized solutions for the double-phase problem with nonlocal reaction

Advances in Nonlinear Analysis
In this article, we consider the double-phase problem with nonlocal reaction. For the autonomous case, we introduce the methods of the Pohozaev manifold, Hardy-Littlewood Sobolev subcritical approximation, adding the mass term to prove the existence and ...
Cai Li, Zhang Fubao
doaj   +1 more source

Multiple normalized solutions for a competing system of Schrödinger equations [PDF]

, 2022
Thomas Bartsch, Nicola Soave
openalex   +1 more source

Centro-affine curvature flows on centrally symmetric convex curves [PDF]

, 2012
We consider two types of $p$-centro affine flows on smooth, centrally symmetric, closed convex planar curves, $p$-contracting, respectively, $p$-expanding. Here $p$ is an arbitrary real number greater than 1. We show that, under any $p$-contracting flow,
Ivaki, Mohammad N.
core  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Normalized solutions for Sobolev critical fractional Schrödinger equation

Advances in Nonlinear Analysis
In the present study, we investigate the existence of the normalized solutions to Sobolev critical fractional Schrödinger equation: (−Δ)su+λu=f(u)+∣u∣2s*−2u,inRN,(Pm)∫RN∣u∣2dx=m2,\hspace{14em}\left\{\begin{array}{ll}{\left(-\Delta )}^{s}u+\lambda u=f ...
Li Quanqing, Nie Jianjun, Wang Wenbo, Zhou Jianwen   +3 more
doaj   +1 more source

Normalized solutions for Kirchhoff equations with Choquard nonlinearity: mass Super-Critical Case

Communications in Analysis and Mechanics
In the present paper, we investigated the existence of normalized solutions for the following Kirchhoff equation with Choquard nonlinearity$ \begin{equation*} -\Big(a+b\int_{\mathbb{R}^{3}}|\nabla u|^{2}dx\Big)\Delta u-\lambda u = \mu|u|^{q-2}u+(I_ ...
Zhi-Jie Wang, Hong-Rui Sun
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Non-singular solutions to the normalized Ricci flow equation [PDF]

, 2022
Fuquan Fang, Yuguang Zhang, Zhenlei Zhang   +2 more
openalex   +1 more source