Results 111 to 120 of about 1,922 (252)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
On Suborbital Graphs for the Normalizer of Gamma(0)(N)
, 2009 where n>1, v is an element of Q boolean OR {infinity} and T is an elliptic mapping of order k in the normalizer of Gamma(0)(N)
Keskin, Refik, Demirtürk Bitim, Bahar
core
The normalizer splitting conjecture for p-compact groups [PDF]
, 1999 Let X be a p-compact group, with maximal torus BT → BX, maximal torus normalizer BN and Weyl group $W_X$. We prove that for an odd prime p, the fibration $BT → BN → BW_X$ has a section, which is unique up to vertical ...
Andersen, Kasper
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On Π-Normal Subgroups and the p-Supersolvability of Finite Groups
AxiomsRather than using all maximal subgroups of a Sylow p-subgroup, we work with a prescribed subfamily. For a p-solvable group G, we show that p-supersolvability follows when the members of this subfamily are Π-normal in the Sylow normalizer and when G ...
Jiawen He +3 more
doaj +1 more source
Centralizer, center, dan normalizer subgrup di grup dihedral-2n (D_2n,°) [PDF]
, 2011 INDONESIA: Beberapa pokok bahasan dalam Aljabar adalah centralizer, center, dan normalizer subgrup di grup dihedral-2n (D_2n,°). Grup dihedral-2n (D_2n,°) adalah kumpulan dari simetri-simetri poligon n beraturan yang terdiri dari rotasi dan refleksi ...
Rahma, Emma Provita
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Layer-finiteness of Some Groups
Известия Иркутского государственного университета: Серия "Математика"Infinite groups with finiteness conditions for an infinite system of subgroups are studied. Groups with a condition: the normalizer of any non-trivial finite subgroup is a layer-finite group or the normalizer of any non-trivial finite subgroup has a ...
V.I. Senashov
doaj +1 more source