Results 101 to 110 of about 1,922 (252)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Kingfisher: A hybrid LLM-augmented Bangla text normalization for enhanced text-to-speech

Natural Language Processing Journal
Text normalization (TN), the process of converting non-standard words into their spoken equivalents, is a fundamental pre-processing step for text-to-speech (TTS) systems.
Rajan Saha Raju, Arif Ahmad, Mohammad Shahidur Rahman   +2 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Epimetheus - a multi-profile normalizer for epigenomic sequencing data

BMC Bioinformatics, 2017
Background Exponentially increasing numbers of NGS-based epigenomic datasets in public repositories like GEO constitute an enormous source of information that is invaluable for integrative and comparative studies of gene regulatory mechanisms.
Mohamed-Ashick M. Saleem, Marco-Antonio Mendoza-Parra, Pierre-Etienne Cholley, Matthias Blum, Hinrich Gronemeyer   +4 more
doaj   +1 more source

Lifting involutions in a Weyl group to the torus normalizer

, 2018
Let N be the normalizer of a maximal torus T in a split reductive group over Fq, and let w be an involution in theWeyl group N/T. We explicitly construct a lifting n of w in N such that the image of n under the Frobenius map is equal to the inverse of ...
Lusztig, George, G. Lusztig
core   +1 more source

Normalizer: Augmenting Code Clone Detectors Using Source Code Normalization [PDF]

, 2017
Code clones are duplicate fragments of code that perform the same task. As software code bases increase in size, the number of code clones also tends to increase.
Ly, Kevin
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Recommendation System Yogyakarta Tourism Using TF-IDF and Cosine Similarity Methods with Word Normalizer

Journal of Applied Informatics and Computing
The abundance of tourism information in Yogyakarta often overwhelms tourists due to non-standard text data. This research develops a tourism recommendation system using Content-Based Filtering by integrating TF-IDF and Cosine Similarity algorithms ...
Jauhar Fauzi Ulul Albab, Arif Nur Rohman
doaj   +1 more source

On the normalizer of an iterated wreath product [PDF]

, 2023
Given a group $G$ and $n\geq 0$, let $W(G,n)$ be the associated iterated wreath product -- unrestricted when $G$ is infinite -- viewed as a permutation group on $G^n$.
Szechtman, Fernando
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source