Results 81 to 90 of about 23,452 (277)
Epimetheus - a multi-profile normalizer for epigenomic sequencing data
BMC Bioinformatics, 2017 Background Exponentially increasing numbers of NGS-based epigenomic datasets in public repositories like GEO constitute an enormous source of information that is invaluable for integrative and comparative studies of gene regulatory mechanisms.
Mohamed-Ashick M. Saleem +4 more
doaj +1 more source
The period functions' higher order derivatives [PDF]
, 2012 We prove a formula for the $n$-th derivative of the period function $T$ in a period annulus of a planar differential system. For $n = 1$, we obtain Freire, Gasull and Guillamon formula for the period's first derivative \cite{FGG}.
Sabatini, Marco
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Kingfisher: A hybrid LLM-augmented Bangla text normalization for enhanced text-to-speech
Natural Language Processing JournalText normalization (TN), the process of converting non-standard words into their spoken equivalents, is a fundamental pre-processing step for text-to-speech (TTS) systems.
Rajan Saha Raju +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Journal of Applied Informatics and ComputingThe abundance of tourism information in Yogyakarta often overwhelms tourists due to non-standard text data. This research develops a tourism recommendation system using Content-Based Filtering by integrating TF-IDF and Cosine Similarity algorithms ...
Jauhar Fauzi Ulul Albab, Arif Nur Rohman
doaj +1 more source
Classical simulations of Abelian-group normalizer circuits with intermediate measurements
, 2013 Quantum normalizer circuits were recently introduced as generalizations of Clifford circuits [arXiv:1201.4867]: a normalizer circuit over a finite Abelian group $G$ is composed of the quantum Fourier transform (QFT) over G, together with gates which ...
Bermejo-Vega, Juan +1 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source