Results 191 to 200 of about 64,482 (311)

A Review on Data Normalization Techniques [PDF]

, 2020
Kalyani A Sankpal
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Development and Validation of a Capillary Electrophoresis Coupled to Mass Spectrometry Pipeline for Comparable Assessment of the Plasma Peptidome. [PDF]

Proteomics
Fernandez L, Breuil B, Froment C, Seye M, Sylla B, Estanco M, Chaubet A, Delecroix E, Chaoui K, Vu JP, Ardeleanu S, Faguer S, Burlet-Schiltz O, Buffin-Meyer B, Schanstra JP, Klein J.   +15 more
europepmc   +1 more source

Molecular Insight into Iron Homeostasis of Acute Myeloid Leukemia Blasts. [PDF]

Int J Mol Sci, 2023
Pourcelot E, El Samra G, Mossuz P, Moulis JM.   +3 more
europepmc   +1 more source

Self-normalized moderate deviations for independent random variables

, 2012
Bing‐Yi Jing, Han‐Ying Liang, Wang Zhou   +2 more
openalex   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Analysis of qRT-PCR Data to Identify the Most Stable Reference Gene Using gQuant. [PDF]

Bio Protoc
Pathak AK, Kural S, Singh S, Kumar L, Gupta M, Jain G.   +5 more
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

A plasma miRNA signature, including miR-495, as early diagnostic biomarkers associated with cognitive decline in Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Cots A, Riberas-Sánchez A, Pericot I, Turon A, García-Brito S, Garre-Olmo J, Puig J, Fernández-Real JM, Ramos R, Huguet G, Carreras-Badosa G, Kadar E.   +11 more
europepmc   +1 more source