Results 71 to 80 of about 1,460,279 (263)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Bounded-Monitor Placement in Normative Environments [PDF]

open access: yes, 2017
ISSN: 16130073 Funding: This work is partially supported by grants from CNPq/Brazil numbers 132339/2016-1 and 305969/2016-1.Publisher ...
Krzisch, Guilherme   +2 more
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer   +3 more
wiley   +1 more source

Political Thought as Interdisciplinary Knowledge: A Paradigmatic-Implicative Narration [PDF]

open access: yesInterdisciplinary Studies in the Humanities, 2015
Political thought is the kind of thinking which is formulated in different disciplines; political philosophy, political ideology, political theology, and political literature are some of its important examples. Although in the course of history political
A. Manoochehri
doaj   +1 more source

Aesthetic Internalism and two Normative Puzzles [PDF]

open access: yes, 2016
One of the most discussed views in metaethics is Moral Internalism, according to which there is a conceptually necessary connection between moral judgments and motivation to act.
Strandberg, Caj
core  

A solution to the many attitudes problem [PDF]

open access: yes, 2020
According to noncognitivism, normative beliefs are just desire-like attitudes. While noncognitivists have devoted great effort to explaining the nature of normative belief, they have said little about all of the other attitudes we take towards normative ...
Beddor, Bob
core  

Recklessness and Uncertainty: Jackson Cases and Merely Apparent Asymmetry [PDF]

open access: yes, 2019
Is normative uncertainty like factual uncertainty? Should it have the same effects on our actions? Some have thought not. Those who defend an asymmetry between normative and factual uncertainty typically do so as part of the claim that our moral beliefs ...
Field, Claire
core   +2 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

A failure to communicate

open access: yesErasmus Journal for Philosophy and Economics, 2013
This paper considers the debate between economists and philosophers about the role of values in economic analysis by examining the recent debate between Hilary Putnam and Sir Partha Dasgupta.
Huei-chun Su, David Colander
doaj   +1 more source

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