Results 51 to 60 of about 1,400,848 (384)

“Ethical Minefields” and the Voice of Common Sense: A Discussion with Julian Savulescu [PDF]

open access: yes, 2019
Theoretical ethics includes both metaethics (the meaning of moral terms) and normative ethics (ethical theories and principles). Practical ethics involves making decisions about every day real ethical problems, like decisions about euthanasia, what we ...
Protopapadakis, Evangelos D.   +1 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Ethical Aspects of Some Related Concepts of Corporate Responsibility

open access: yesMednarodno Inovativno Poslovanje, 2022
The article discusses the concepts of corporate responsibility as a concept of applied ethics and connects philosophical and social science approaches and insights from the point of view of philosophical (normative) ethics.
Vida Sruk, Pedja Ašanin Gole
doaj   +1 more source

Sidgwick’s coherentist moral epistemology [PDF]

open access: yes, 2012
I discuss the ideas of common sense and common-sense morality in Sidgwick. I argue that, far from aiming at overcoming common-sense morality, Sidgwick aimed purposely at grounding a consist code of morality by methods allegedly taken from the natural ...
Cremaschi, Sergio Volodia Marcello
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Why Ethics Requires a God and Is Safer from Evolutionary Debunking Threats as a Result: A Reply to Sterba

open access: yesReligions
Sterba has argued that ethics does not require God and that an atheistic objectivist ethics is compatible with an evolutionary account of our development.
Gerald K. Harrison
doaj   +1 more source

Beyond normative ethics: Ethics of arts-based disability research

open access: yes, 2015
Summary In Western culture, the pervading medical model of disability has characterized disability as a problem in need of a solution: an unwanted condition that demands a cure.
R. Mykitiuk, Amy Chaplick, Carla M. Rice
semanticscholar   +1 more source

Corporate ethical identity as determinant of firm performance : a test of the mediating role of stakeholder satisfaction [PDF]

open access: yes, 2005
In this article, we empirically assess the impact of the Corporate Ethical Identity (CEI) on the firm's financial performance. Drawing on formulation of both normative and instrumental stakeholder theory, we argue that firms with a strong ethical ...
Berrone, Pascual Alberto   +2 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

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