Results 51 to 60 of about 485,319 (308)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Risk assessment of genetically modified food and neoliberalism: An argument for democratizing the regulatory review protocol of the Food and Drug Administration [PDF]

, 2014
The primary responsibility of the US Food and Drug Administration is to protect public health by ensuring the safety of the food supply. To that end, it sometimes conducts risk assessments of novel food products, such as genetically modified food.
Meghani, Zahra
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

COMMON ISSUES OF NATIONAL AND ANGLO-AMERICAN (ANALYTICAL) LEGAL POSITIVISM

Правовое государство: теория и практика
The article examines the issue of finding the basis for common ground and scientific dialogue between national legal positivism and analytical positivism represented in common law countries.
GORBUNOV Maxim Dmitrievich
doaj   +1 more source

MODERN REQUIREMENTS TO INDUSTRIAL PRODUCTION AND PHARMACEUTICAL MANUFACTURE OF INFUSION MEDICINAL PREPARATIONS IN THE RUSSIAN FEDERATION: SIMILARITIES AND DIFFERENCES

Фармация и фармакология (Пятигорск), 2018
The quantitative reduction of the manufacturing pharmaceutical organizations significantly lowers public accessibility to medicinal preparations manufactured by pharmacies.
R. A. Gachenko, A. B. Goryachev
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Motivating Students With Dyslexia: The Debilitating Effects of Normative Performance Goals on Their Physiological Arousal

Frontiers in Education, 2022
The present study tested the hypothesis that normative vs. non-normative performance goals would be associated with significantly divergent pathways in relation to both cognitive and emotional regulation.
Ghadah S. Alkhadim
doaj   +1 more source

Exploring the dynamics of compliance with community penalties [PDF]

, 2008
In this paper, we examine how compliance with community penalties has been theorized hitherto and seek to develop a new dynamic model of compliance with community penalties. This new model is developed by exploring some of the interfaces between existing
Ayres, Ian, Bottoms, Anthony, Braithwaite, Valerie, Ellis, Tom, Fergus McNeill, Gwen Robinson, Hawkins, Keith, Hearnden, Ian, Hedderman, Carol, Her Majesty's Inspectorate of Probation, Hirschi, Travis, Home Office, Home Office, Home Office, Home Office, Home Office, Hough, Mike, Hucklesby, Anthea, Kagan, Robert A., Kagan, Robert A., Kemshall, Hazel, Kemshall, Hazel, May, Chris, McBarnet, Doreen, McIvor, Gill, Morgan, Rod, Murphy, Kristina, Nellis, Mike, Power, Michael, Raynor, Peter, Raynor, Peter, Reiss, Albert J., Roberts, Colin, Robinson, Gwen, Scottish Executive, Sherman, Lawrence W., Social Work Inspection Agency, Social Work Inspection Agency, Tyler, Tom R., Tyler, Tom R.   +39 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Normative legal regulation of physical education of preschool children

Слобожанський науково-спортивний вісник, 2019
Purpose: analysis and generalization of the legal regulation of the physical education of children in school and out-of-school time. Material & Methods: in the course of the study, methods of analysis of literary sources and documents, induction and ...
Taras Bondar, Iryna Holoviichuk
doaj   +1 more source