Results 111 to 120 of about 2,338,916 (290)
Social norm strength and norm change
Current Opinion in PsychologySocial norms vary both in terms of their content (e.g. don't talk to strangers, help the needy) and their strength. While most research focuses on the former, increasing evidence points to the relevance of the latter for norm change. Despite this potential, existing knowledge about norm strength is siloed into "macro" and "micro" perspectives, with the
Aron Szekely +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ambivalence, Distance, and Conflict in Ancient Literature
ClothoSocietal, political, and religious norms influence the way people speak, think, act, and write. In antiquity, violation of these norms was severely punished with exile by those found guilty of a misdeed or of offending the gods.
Darja Šterbenc Erker
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Norms, Normative Utterances, and Normative Propositions
, 2006 It is argued that the distinction between the normative and the descriptive interpretation of norm sentences can be regarded as a distinction between two kinds of utterances. A norm or a directive has as its content a normative proposition. A normative (performative) utterance of a normative proposition in appropriate circumstances makes the ...
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
School bullying: children and adolescent norms, cultures and identity development
Frontiers in EducationIntroductionSchool bullying arises from a system of peers who form bonds through the repeated victimization of others. This empirical research article examines the function of bullying within the context of children and adolescent norms and cultures ...
Zoe Moody +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2011 Tania E. Strahan
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
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