Results 111 to 120 of about 890,913 (263)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

THE RELEVANCE OF MACNEIL'S RELATIONAL NORMS TO UNDERSTAND THE EXIT OF A INTERORGANIZATIONAL RELATIONSHIP [PDF]

open access: yes
Relationship marketing has been gaining an increasing interest in the marketing community for the past ten years. Some authors define relationship building and management as the core of the marketing process (Grönroos, 1994), others view it as a way to ...
Isabelle Prim-Allaz, Jean Perrien
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Homo Socionicus: a Case Study of Simulation Models of Norms [PDF]

open access: yes
This paper describes a survey of normative agent-based social simulation models. These models are examined from the perspective of the foundations of social theory. Agent-based modelling contributes to the research program of methodological individualism.
Martin Neumann
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

An Experimental Study of Conventions and Norms [PDF]

open access: yes
Although it is now recognized that norms play an important role in many economic decisions, compliance with conventions is generally considered to be driven by rational self-interest only.
Luigi Mittone, Francesco Guala
core  

The effects of a social norms marketing message on self-reported drinking behaviors of college students [PDF]

open access: yes, 2001
Plan BThis pilot study investigated the immediate effects of providing college students with social norms messages regarding peer alcohol consumption on a self-report measure of drinking behaviors.
Siders, Jennifer J.
core  

NPE - A Conceptual Model and Language for the Representation of Norms

open access: yes
Originating in Deontic logic, norms and normative facts enable philosophers, designers and developers to reason over actions an actor may or may not perform with respect to social rules.
Walters, Robert   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Social capital, social norms and the New Institutional Economics [PDF]

open access: yes
Douglass North (1990) describes institutions as the rules of the game that set limits on human behavior, now a universally-accepted definition. North and others especially underline the crucial role of informal social norms.
Keefer, Philip, Knack, Stephen
core  

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