Results 81 to 90 of about 1,696,544 (312)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
SPORT PRACTICES IN BIHAR AND UTTAR PRADESH: MAKING OF “SPORTS SOCIOLOGY” IN INDIA
Мониторинг общественного мнения: экономические и социальные перемены, 2018 The ‘problem of normativity’ concerns the role that society’s value system, norms and conventions play in legislative regulation. Rapid social change was always problematic, for example the swift displacement of French Revolutionary law by the Napoleonic
Margaret. S. ARCHER
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Against healthism in dementia prevention: Sharing responsibility
Aging Medicine, 2023 Timothy Daly
doaj +1 more source
Norms in Perspective: Norms about norms - a Hartian perspective
, 2013 My purpose in this article is to make a contribution to what the legal philosopher H.L.A. Hart (1907-1992) has to say about providing a sociological understanding of law and to apply Hart's theory in relation to a specific area of law. The specific legal
Dahlstrand, Karl,, Lund University.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
From Rituals to Practices: Civil Religion as a Subject of E. Durkheim’s Socio-Philosophical Concept
RUDN Journal of PhilosophyThe research proposes reassembly of the concept of civil religion with reference to the work of E. Durkheim, which, according to the authors, can contribute to the development of general theoretical and methodological foundations and epistemology of ...
Daniil A. Anikin, Oksana V. Golovashina
doaj +1 more source
Impact of crime on economic development of the Russian regions
Russian Journal of Economics and Law, 2019 Objective: to analyze the impact of crime as a social capital measure on economic growth in the regions and municipalities of the Russian Federation.Methods: general scientific methods of analysis and synthesis; econometric modeling.Results: the paper ...
A. A. Shakirova, T. V. Kramin
doaj +1 more source
Tax Evasion, Social Norms and Conditional Cooperation [PDF]
Tax Evasion; Social Norms; Conditional ...
Traxler, Christian
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source