Results 41 to 50 of about 26,674 (218)
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science, EarlyView.This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang +9 more
wiley +1 more source
Fucose Binding Cancels out Mechanical Differences between Distinct Human Noroviruses
Viruses, 2023 The majority of nonbacterial gastroenteritis in humans and livestock is caused by noroviruses. Like most RNA viruses, frequent mutations result in various norovirus variants.
Yuzhen Feng +5 more
doaj +1 more source
Advancing Food Safety in Bangladesh: Challenges and the Promise of Smart Sensor Technology
Food Safety and Health, EarlyView.This study critically analyzes prevalent food safety hazards in Bangladesh and identifies key challenges in food safety practices and regulations. It discusses factors influencing food safety and explores strategies to enhance public health. Additionally, advancements in smart sensor‐based detection methods for food hazards are highlighted to offer ...
Md Wadud Ahmed, Mohammed Kamruzzaman
wiley +1 more source
Pathogens, 2023 Norovirus causes a large proportion of pediatric acute gastroenteritis (AGE) worldwide, and no vaccines are currently available. To inform public health measures against norovirus gastroenteritis, we assessed risk factors in a case–control study nested ...
Nadja Alexandra Vielot +6 more
doaj +1 more source
iMeta, EarlyView.Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang +12 more
wiley +1 more source
Revista Peruana de Pediatría, 2014 Norovirus (NoV) es la causa más común de gastroenteritis aguda esporádica o epidémica en niños en edad escolar, adolescentes y adultos. En lactantes y niños pequeños, es la segunda más frecuente después de rotavirus. La diversidad entre los NoV es muy grande. Se distinguen 5 genogrupos (G) y 29 genotipos; las cepas humanas
Eduardo Salazar Lindo +1 more
openaire +1 more source
Clinical characteristics and risk factors for children with norovirus gastroenteritis in Taiwan
Journal of Microbiology, Immunology and Infection, 2021 Background: Norovirus is a common acute gastroenteritis (AGE) pathogen across all age groups worldwide, which is difficult to differentiate from other pathogens.
Chia-Yi Wu +12 more
doaj
Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
Emerging Infectious Diseases, 2021 A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported.
Marie Hagbom +6 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu +7 more
wiley +1 more source
Viruses, 2019 Human norovirus is the major cause of non-bacterial epidemic gastroenteritis. Human norovirus binds to environmental solids via specific and non-specific interactions, and several specific receptors for human norovirus have been reported.
Mohan Amarasiri, Daisuke Sano
doaj +1 more source