Results 51 to 60 of about 26,421 (155)

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

MedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang, Jianheng Zhu, Xiang Peng, Kanghua Zhong, Ming Zou, Xi Yang, Qiuhua Wang, Changjun Nie, Chaorui Tang, Ning Tang, Lanlan Geng, Hanhan Chen, James E. Vince, Hirokazu Kanegane, Xiaodong Zhao, Huifang Xian, Wenhao Zhou, Min Zhi, Yuxia Zhang, Zhanghua Chen   +28 more
wiley   +1 more source

Norovirus Infection in Harbor Porpoises

Emerging Infectious Diseases, 2017
A norovirus was detected in harbor porpoises, a previously unknown host for norovirus. This norovirus had low similarity to any known norovirus. Viral RNA was detected primarily in intestinal tissue, and specific serum antibodies were detected in 8 (24%)
Miranda de Graaf, Rogier Bodewes, Cornelis E. van Elk, Marco van de Bildt, Sarah Getu, Georgina I. Aron, Georges M.G.M. Verjans, Albert D.M.E. Osterhaus, Judith M.A. van den Brand, Thijs Kuiken, Marion P.G. Koopmans   +10 more
doaj   +1 more source

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Mitigating Microbial Contamination in Fresh Fruits and Vegetables Using Ultraviolet C Irradiation: A Review

Food Safety and Health, Volume 4, Issue 2, Page 272-279, April 2026.
Although fresh produce is extremely perishable and contaminated, it is essential for good health. To eliminate important foodborne pathogens, this paper investigates UV‐C irradiation as a safe, nonthermal technique. UV dose, exposure duration, and product characteristics all affect effectiveness.
Krish Rauniyar, Ruplal Choudhary
wiley   +1 more source

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Human noroviruses are a leading cause of acute gastroenteritis worldwide, yet the molecular principles governing antibody recognition of their highly repetitive capsid remain poorly understood. Here, we immunized mice with virus‐like particles (VLPs) from the pandemic GII.4 strain and the emergent GII.17 strain, generating monoclonal IgM and ...
Jumpei Tagawa, Saeko Yanaka, Yuri Kato, Akitsu Masuda, Jae Man Lee, Akinobu Senoo, Kosuke Oyama, Takayuki Uchihashi, Motohiro Nishida, Takahiro Kusakabe, Jose M. M. Caaveiro   +10 more
wiley   +1 more source

Preventing Foodborne Illness: Norovirus

EDIS, 2015
If you have ever had the stomach flu, norovirus was likely the culprit. Norovirus is the most common cause of foodborne illness in the United States and is transmitted through direct person-to-person contact or contaminated objects and food.
Rachael Silverberg, Melissa K. Jones, Renée Goodrich Schneider, Aswathy Sreedharan, Keith R. Schneider   +4 more
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Pancreas Transplantation in the Modern Era: Observations and Implications of Donor Pancreas Extraction Time

Clinical Transplantation, Volume 40, Issue 4, April 2026.
ABSTRACT There has been a worldwide reduction in pancreas transplant volume over the last decade. Understanding factors, such as procurement extraction time (ET), that play a key role in organ recovery can increase confidence in organ acceptance and improve organ utilization.
Michael A. Deal, Christof Kaltenmeier, Perwaiz Nawabi, Steven I. Hanish, Prabhakar Baliga, Santosh Nagaraju, Kannan Samy, Dirk J. van der Windt, Diego DiSabato, John W. McGillicuddy, David J. Taber, Joseph R. Scalea   +11 more
wiley   +1 more source

No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel

Human Vaccines & Immunotherapeutics, 2019
Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and
Khitam Muhsen, Eias Kassem, Uri Rubenstein, Sophy Goren, Moshe Ephros, Lester M. Shulman, Dani Cohen   +6 more
doaj   +1 more source

Norovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chile

International Journal of Infectious Diseases, 2020
Objective: To determine the dynamics of norovirus disease, a major cause of acute gastroenteritis (AGE), compared to other relevant etiologies, among families living in a lower middle income area.
Yalda Lucero, Anne J. Lagomarcino, Mónica Espinoza, Nanami Kawakami, Nora Mamani, Nicole Huerta, Felipe Del Canto, Mauricio Farfán, Yoshihiro Sawaguchi, Sergio George, Miguel O’Ryan   +10 more
doaj   +1 more source