Results 51 to 60 of about 32,837 (163)

Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft‐Versus‐Host Disease After Pediatric Liver Transplantation

Pediatric Transplantation, Volume 29, Issue 7, November 2025.
ABSTRACT Background and Aim Though liver transplantation (LT) is effective for pediatric patients with end‐stage liver disease, it is associated with complications such as graft‐versus‐host disease (GVHD). In part due to its rarity and lack of standardized therapy, post‐LT GVHD is associated with a high mortality rate.
Keisuke Sawada, Pooja Khandelwal, Stella M. Davies, Anna Crooker, Tomoyuki Mizuno, Akihiro Asai   +5 more
wiley   +1 more source

Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research

Movement Disorders Clinical Practice, EarlyView.
Alberto J. Espay, Andrew J. Lees
wiley   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Epidemiology of norovirus disease in the first 2 years of life: A prospective multisite cohort study in Lima, Peru

International Journal of Infectious Diseases
Objectives: Norovirus is associated with 18% of acute gastroenteritis (AGE) cases worldwide. We aim to document the norovirus-related AGE incidence in peri-urban areas of Lima (Peru), evaluating the potential impact of a norovirus vaccine introduction ...
Claudio F. Lanata, Giselle Soto, Ana I. Gil, Joan Neyra, Rubelio Cornejo, Candice Romero, Lucie Ecker, Maria L. Huaylinos, Sayda La Rosa, Ana Goios, Astrid Borkowski, John Weil   +11 more
doaj   +1 more source

CRISPR‐driven diagnostics: Molecular mechanisms, clinical efficacy and translational challenges

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
The CRISPR/Cas system has emerged as a transformative tool in the field of molecular diagnosis, offering unprecedented sensitivity, specificity and rapid detection capabilities. This review further examines the molecular mechanisms of CRISPR tools, compares their clinical efficacy with traditional methods and highlights cutting‐edge innovations such as
Zilong Wang, Qianqian Wang, Jiaming Zhang, Bingyu Li, Yuke Li, Zhengbo Chen, Dandan Guo, Shuying Feng   +7 more
wiley   +1 more source

Norovirus MLKL-like protein initiates cell death to induce viral egress [PDF]

, 2023
Guoxun Wang, Di Zhang, Robert C. Orchard, Dustin C. Hancks, Tiffany A. Reese   +4 more
openalex   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel

Human Vaccines & Immunotherapeutics, 2019
Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and
Khitam Muhsen, Eias Kassem, Uri Rubenstein, Sophy Goren, Moshe Ephros, Lester M. Shulman, Dani Cohen   +6 more
doaj   +1 more source

Norovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chile

International Journal of Infectious Diseases, 2020
Objective: To determine the dynamics of norovirus disease, a major cause of acute gastroenteritis (AGE), compared to other relevant etiologies, among families living in a lower middle income area.
Yalda Lucero, Anne J. Lagomarcino, Mónica Espinoza, Nanami Kawakami, Nora Mamani, Nicole Huerta, Felipe Del Canto, Mauricio Farfán, Yoshihiro Sawaguchi, Sergio George, Miguel O’Ryan   +10 more
doaj   +1 more source

Minimum Inhibitory Concentrations of Anidulafungin as a Potential Predictor of Biocide Susceptibility of Clade 1 Candidozyma (Candida) auris Isolates

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Our study shows that a decision tree trained on antifungal MIC profiles, especially anidulafungin, can predict how susceptible Candida auris is to triclosan, chlorine, and chlorhexidine. This shows a possible way to cut down on routine biocide testing in infection control surveillance. ABSTRACT Candidozyma (Candida) auris is a multidrug‐resistant yeast
Sidre Erganis, Ayse Seyer, Mubarak Taiwo Mustapha, Meliz Yuvali, Furkan Martli, Sena Algin, Sema Turan Uzuntas, Beyza Yavuz, Alper Dogan, Esra Kılıc, Fusun Kirca, Abdullahi Garba Usman, Elif Ayca Sahin, Cagrı Ergin, Bedia Dinc, Dilber Uzun Ozsahin, Ayse Kalkanci   +16 more
wiley   +1 more source