Results 141 to 150 of about 2,924,837 (312)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
“Apostle of Ethnology”: Agnes C. L. Donohugh’s Missiological Anthropology between the World Wars
, 2016 Agnes C. L. Donohugh (1876–1966) taught at Hartford Theological Seminary’s Kennedy School of Missions between 1918 and 1944, the leading graduate program in mission studies in North America prior to World War II.
Hartley, Benjamin
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Brasileira de Estudos da Presença, 2016 Este trabalho propõe um questionamento dos princípios fundamentais do método Bailarino-Pesquisador-Intérprete (BPI) ensinado na Universidade Estadual de Campinas (Unicamp), no Brasil.
Ana Paula Hofling (University of North Carolina – Greensboro, Estados Unidos da América)
doaj
Mobility decisions of European doctoral researchers. [PDF]
Student mobility remains an important component for the completion of a European Higher Education and Research Area. Two issues at the forefront are increasing student mobility within Europe as well as worries about a ‘brain drain’ of talented graduate ...
Lykogianni, Elissavet +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Revista Brasileira de Estudos da Presença, 2016 This paper calls into question the central tenets of the Dancer-Researcher-Performer (BPI) method taught at the Universidade Estadual de Campinas (Unicamp) in Brazil. The analysis problematizes the underlying assumption that students lack an awareness of
Ana Paula Hofling (University of North Carolina – Greensboro, United States of America)
doaj
Evolution of quantum spin sensing: From bench-scale ODMR to compact integrations
APL MaterialsThis paper provides a comprehensive review of quantum spin sensing with a focus on the nitrogen vacancy (NV) center in diamond. Beginning with the discovery of optically detected magnetic resonance in NV centers, we trace the evolution of this technology
Shahriar Esmaeili +10 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source