Results 121 to 130 of about 5,504,994 (361)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Matching estimators of causal effects in clustered observational studies

open access: yesJournal of Causal Inference
Marine conservation preserves fish biodiversity, protects marine and coastal ecosystems, and supports climate resilience and adaptation. Despite the importance of establishing marine protected areas (MPAs), research on the effectiveness of MPAs with ...
Cui Can   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

North Carolina Association of Future Homemakers of America Records - Accession 350 - M140 (176)

open access: yes, 2015
The North Carolina Association of Future Homemakers of America\u27s goal is to help youth assume their roles in society through home economics education in areas of personal growth, family life, vocational preparation and community involvement.
Future Homemakers of America, North Carolina
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A monograph of the bats of North America

open access: yesBulletin of the United States National Museum, 1893
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
openaire   +6 more sources

DEFAULTER, Late Acting Teller Traders Bank of Canada, Strathroy, Canada, ABSCONDED MARCH 10, 1895,

open access: yes, 1895
$500 REWARD! JOHN W. PATTERSON, DEFAULTER, Late Acting Teller Traders Bank of Canada, Strathroy, Canada, ABSCONDED MARCH 10, 1895, Was Bonded by the Guarantee Co. of North America. DESCRIPTION: Eighteen years of age; height, 5 feet 6 inches; build,
Guarantee Company of North America
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Mapping isoprene emissions over North America using formaldehyde column observations from space

open access: yes, 2003
We present a methodology for deriving emissions of volatile organic compounds (VOC) using space-based column observations of formaldehyde (HCHO) and apply it to data from the Global Ozone Monitoring Experiment (GOME) satellite instrument over North ...
Chance, Kelly   +22 more
core   +1 more source

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