Results 141 to 150 of about 31,837 (257)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Precipitation observing network gaps limit climate change impact assessment. [PDF]

Nature
Su J, Miao C, Zwiers F, Beck H, Jones P, Sun Q, Slater LJ, Berghuijs WR, Wada Y, Rosenfeld D, Gou J, Wu Y, Tarolli P, Borrelli P, Panagos P, Alexander LV, Zhang Q, Hu J, Min SK, Samaniego L, Duan Q, Destouni G, Marengo JA, Modarres R, Sorooshian S.   +24 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Evolving landscape of methicillin-resistant Staphylococcus pseudintermedius: the emergence of new epidemic waves across Europe, Asia and North America. [PDF]

J Antimicrob Chemother
Giarratana LR, Pirolo M, Roch FF, Conrady B, Guardabassi L.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Adoption and challenges of the 2018 International Society for Heart and Lung Transplantation consensus statement on adult and pediatric airway complications grading system in lung transplantation: A multicenter survey. [PDF]

JHLT Open
Crespo MM, Solé A, Bermudez CA, Richards TJ, Mazur Z, Budev M.   +5 more
europepmc   +1 more source

Lithospheric Fabric in Central North America: the Superior Province and the Mid-Continent Rift

, 2014
Seismic data from 31 seismic stations, consisting of 16 SPREE (Superior Province Rifting Earthscope Experiment) and 15 TA (Transportable Array) instruments located from 80 - 97W and 41 – 55N were used to measure the lateral variation in the lithospheric fabric beneath the Superior Province and the Mid-Continent Rift (MCR). I made shear wave splitting
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

T. indotineae: A New Emergent Fungal Pathogen Driven by Global Travel. [PDF]

Mycoses
Ortiz B, Morio F, Aguilar K, García F, Fontecha G, Moreno-Sabater A.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source