Results 151 to 160 of about 31,837 (257)

Is beta diversity higher in seed plants with larger body sizes? [PDF]

Plant Divers
Qian H.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The evolutionary history and unique genetic diversity of Indigenous Americans. [PDF]

Nature
Castro E Silva MA, Nunes K, Ribeiro MR, Passarelli-Araujo H, Lemes RB, Kimura L, Sacuena P, G Amorim CE, Bortolini MC, Mill JG, Guerreiro JF, Barbieri C, Hernández-Zaragoza DI, Walter A, Chowdhury TN, Macías-Herrera D, Lara-Riegos JC, Del Castillo-Chávez O, Zurita C, Tito-Álvarez AM, Vásquez-Domínguez E, Moo-Mezeta ME, Torres-Romero JC, Aguilar-Campos A, Serrano-Osuna R, Parolín ML, Bravi CM, Ramallo V, Bailliet G, Revollo S, Sandoval JR, Fujita R, Barquera R, Santos FR, Comas D, Hünemeier T.   +35 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

An improved global database and model of plant available soil phosphorus. [PDF]

Sci Data
McDowell RW, Noble ADL, Doscher C, Helfenstein J.   +3 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Dementia's mortality in America: a local, regional, and temporal evaluation. [PDF]

Dement Neuropsychol
Lopes LCP.
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review. [PDF]

BMC Infect Dis
Bosquet A, Affo C, Happe F, Helfer H, Versini E, Mahé I.   +5 more
europepmc   +1 more source