Results 21 to 30 of about 329,068 (264)
Energies, 2023 The “One Belt and One Road” strategy provides a new opportunity for deepening oil and gas energy cooperation between China and Central-North Asian countries.
Mingchen Duan, Yi Duan
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Dizhen xuebao基于唐海—商都宽频带地震台阵2006—2009年连续三年的波形记录，利用环境噪声相位自相关函数对台阵下方的莫霍面反射P波进行分析。通过对同一个台站多个时间段的自相关结果进行分组、采用两步叠加处理增加信号强度：① 在组内进行线性叠加，对组间的叠加结果进行相位加权叠加；② 基于华北地区的背景速度结构信息，在地壳平均速度5%不确定性的时窗内，根据自相关函数包络线的二阶导数最大值确定P波的莫霍面反射时间，经时间−深度转化，获得台阵下方的莫霍面深度。结果显示，莫霍面从东南向西北总体由浅变深，中间有小幅度的起伏 ...
Hongpu Wei, Aihua Zhao
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Infection and Drug Resistance, 2023 Yanhui Wang,1,* Jian Ren,2,* Zhiqing Yao,1 Wei Wang,3 Siyang Wang,2 Junfang Duan,3 Zhen Li,4 Huizi Zhang,1 Ruiqin Zhang,2 Xiaoru Wang3 1College of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of ...
Wang Y +9 more
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FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
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Dizhen xuebao为了解首都圈地区电性莫霍面（eMoho）的分布情况，使用该地区电磁台网部分台站的长周期大地电磁数据，反演得到了首都圈地区的深部电性结构，该结果与前人使用地震、电磁、重力等资料得到的研究区地下结构具有较好的一致性，同时表明首都圈地区的地震学莫霍面附近也存在着电阻率变化特征。在此基础上，对反演所得的电阻率曲线求取一阶导数，以此来刻画测点下方电性莫霍面的深度位置，继而建立三类地层模型验证了该方法的可行性，并对实测资料反演结果求取一阶导数，结果凸显了电性莫霍面的分布，所得电性莫霍面与地震 ...
Kexin Zhu, Xingong Tang, Junhu Yu
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Frontiers in Environmental Science, 2023 Based on hourly station precipitation data and ECMWF ERA5 reanalysis data from 2009 to 2019, this paper explores the temporal variations and spatial distribution of short–duration heavy rainfall (SDHR) induced by North China cold vortices (NCCV) over the
Nan Xing +6 more
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