Results 191 to 200 of about 132,245 (266)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Spatiotemporal changes in riverine input into the Eocene North Sea revealed by strontium isotope and barium analysis of bivalve shells. [PDF]

Sci Rep
Kniest JF, Evans D, Gerdes A, Cantine M, Todd JA, Sigwart JD, Vellekoop J, Müller W, Voigt S, Raddatz J.   +9 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Future trends of marine fish biomass distributions from the North Sea to the Barents Sea. [PDF]

Nat Commun
Gordó-Vilaseca C, Costello MJ, Coll M, Jüterbock A, Reiss H, Stephenson F.   +5 more
europepmc   +1 more source

The North Sea

, 2009
Thomas, Helmuth, Bozec, Yann, de Baar, Hein J. W., Elkalay, Khalid, Frankignoulle, Michel, Kühn, Wilfried, Lenhart, Hermann, Moll, Andreas, Pätsch, Johannes, Radach, Günther, Schiettecatte, Laure-Sophie, Borges, Alberto   +11 more
openaire   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Human response to the Younger Dryas along the southern North Sea basin, Northwest Europe. [PDF]

Sci Rep
Crombé P, Pironneau C, Robert P, van der Sloot P, Boudin M, De Groote I, Verheyden S, Vandendriessche H.   +7 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Vertical and horizontal environmental DNA (eDNA) patterns of fish in a shallow and well-mixed North Sea area. [PDF]

Sci Rep
Dukan N, Cornelis I, Maes S, Hostens K, De Backer A, Derycke S.   +5 more
europepmc   +1 more source