Results 121 to 130 of about 319,839 (313)

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Microblade Industries of Northeast China

Problems of Archaeology, Ethnography, Anthropology of Siberia and Neighboring Territories
Microblade techniques appeared in southern Siberia and spread south and east at the early MIS 2. Northeast China occupies a key geographical position with respect to the spread of microblade technology, as it is bounded by southern Siberia and Mongolia in the west and northwest, the Russian Far East in the northeast, the Japanese Archipelago in the ...
openaire   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Free trade as a force of political stability? The case of mainland China and Hong Kong [PDF]

, 2016
Is free trade a force of political stability? This article argues that, while political stability could be a cause, it is not always a consequence of free trade.
Chan, Vinci, Villalta Puig, Gonzalo
core   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

Impacts of Climate Change on Forest Biodiversity Changes in Northeast China

Remote Sensing
Vegetation plays a vital role in connecting ecosystems and climate features. The biodiversity of vegetation is one of the most important features for evaluating ecosystems and it is becoming increasingly important with the threat of global warming.
Xiguang Yang, Yingqiu Mu, Li Yang, Ying Yu, Zechuan Wu   +4 more
doaj   +1 more source

Volcano‐Inspired Dual‐Carbon Network Aerogel for High‐Performance Solar Evaporation With Edge‐Directed Salt Crystallization and Recovery

Advanced Science, EarlyView.
A volcano‐inspired dual‐carbon aerogel featuring hierarchical conduits and an outer carbon‐fiber shell directs rapid water transport, confines heat, and enables directional salt migration. Radial temperature gradients in the conical structure trigger Marangoni‐driven edge‐localized salt crystallization while maintaining an unobstructed photothermal ...
Shuyue Feng, Yongpeng Wang, Mengzhu Liu, Xin Wang, Tao Jia, Haibo Zhang, Haoyue Wu, Yuan Xu, Linghui Kong   +8 more
wiley   +1 more source

PICES Press, Vol. 12, No. 1, January 2004 [PDF]

, 2004
The state of PICES science - 2003 (pdf 281 KB) 2003 Wooster Award (pdf 764 KB) The state of the eastern North Pacific through summer 2003 (pdf 448 KB) The Bering Sea: Current status and recent events (pdf 951 KB) The state of the western North ...

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