Results 51 to 60 of about 319,839 (313)

利用P波质点运动估算中国东北地区固定台站地震计方位角

open access: yesDizhen xuebao
现代地震研究依赖于可靠的三分量观测数据,地震计的北分量是否严格指北将直接影响研究的准确性。然而,受台站附近磁异常或人为安装错误的影响,地震计的方位角可能出现偏差。基于东北地区154个固定台站2020年的远震数据,利用P波质点运动方法,估算了每个台站的北向分量方位角,以判断台站地震计是否存在方位角偏转问题。结果表明,84%的台站运行良好,12%的台站存在方位角偏差绝对值过大(>20°)或分量极性反转等问题。此外,分析后发现方位角偏转较大会导致H-κ叠加方法计算得到的地壳厚度和地震波速比出现偏差。因此 ...
Guangjie Han, Wenze Deng, Zhigao Yang
doaj   +1 more source

Flora of Northeast Asia

open access: yesPlants, 2023
As a component of the MAP project, the study of the flora in Northeast Asia (comprising Japan, South Korea, North Korea, Northeast China, and Mongolia) convincingly underscores the indispensability of precise and comprehensive diversity data for flora ...
Si-Qi Wang   +4 more
doaj   +1 more source

Modeling soil organic carbon change in croplands of China [PDF]

open access: yes, 2003
Using 1990 conditions, we modeled carbon (C) and nitrogen (N) biogeochemical cycles in croplands of China (and, for comparison, the United States) to estimate the annual soil organic-carbon (SOC) balance for all cropland.
Frolking, Steve   +7 more
core   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

open access: yesAdvanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey   +6 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

open access: yesAdvanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao   +16 more
wiley   +1 more source

Study on the coupling problem of coordinated development of economy–energy–environment–technology system in Northeast China

open access: yesEnergy Reports, 2022
Under the strategy of “Northeast Revitalizing”, Northeast China must correctly handles the coupling relationship of coordinated development among economy, energy, environment, and technology if it insists on the concept of green development.
Yang Yu, Xin Gong
doaj   +1 more source

Outsourcing CO2 within China [PDF]

open access: yes, 2013
Recent studies have shown that the high standard of living enjoyed by people in the richest countries often comes at the expense of CO2 emissions produced with technologies of low efficiency in less affluent, developing countries.
D. Guan   +10 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He   +17 more
wiley   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu   +6 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

open access: yesAdvanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou   +22 more
wiley   +1 more source

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