Results 71 to 80 of about 319,839 (313)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Efficiency of Innovation Ecosystem in Resource-dependent Cities: Empirical Evidence from Northeast China

SAGE Open
As an essential part of national innovation and development, the urban innovation ecosystem supports modernization. Many countries are exploring innovation legislation and improving innovation policies from an ecosystem perspective. As a typical resource-
Dan Li, Yan Chen, Yue Liu
doaj   +1 more source

Evaluation of Population Structure, Genetic Diversity and Origin of Northeast Asia Weedy Rice Based on Simple Sequence Repeat Markers

Rice Science, 2015
Weedy rice exerts a severe impact on rice production by competing for sunlight, water and nutrients. This study assayed the population structure, genetic diversity and origin of Northeast Asia weedy rice by using 48 simple sequence repeat markers.
Li Mao-bai, Wang Hui, Cao Li-ming
doaj   +1 more source

Smoking and lung cancer in Harbin, northeast China

Annals of Oncology, 2005
We studied the relationship between smoking and lung cancer risk in Harbin, Heilongjiang province, northeast China, an area with a very high baseline risk of lung cancer in both sexes, using data from a case-control study of lung cancer conducted between 1987 and 1990.Cases were 218 patients with incident, histologically confirmed lung cancer and ...
J, Hu, C, Galeone, R, Lui, C, Pelucchi, C, La Vecchia, E, Negri   +5 more
openaire   +4 more sources

Identifying hotspots and management of critical ecosystem services in rapidly urbanizing Yangtze River Delta Region, China [PDF]

, 2017
Rapid urbanization has altered many ecosystems, causing a decline in many ecosystem services, generating serious ecological crisis. To cope with these challenges, we presented a comprehensive framework comprising five core steps for identifying and ...
Cai, Wenbo, Cai, Yongli, Ferrier, Graham, Gibbs, David, Zhang, Lang   +4 more
core   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Migrants in their family contexts: Application of a methodology [PDF]

, 2000
The composition of immigrant families is a topic which has attracted considerable public and political attention in recent years. In the late 1980s concern was expressed over the size of some households of Pacific Island peoples in New Zealand.
Bedford, Charlotte, Bedford, Richard, Ho, Elsie   +2 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Voluntary frontier settlement and independent agency within China

Acta Psychologica
Voluntary frontier settlement has led to independent agency in Western and a few non-Western societies. This study suggests that Northeast China was constructed as a new region with voluntary frontier settlers during 1860–1920, and examined whether ...
Xiaopeng Ren, Yiwei Zhang
doaj   +1 more source