Results 11 to 20 of about 392,850 (309)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

The landscape of somatic copy-number alteration across human cancers [PDF]

, 2010
available in PMC 2010 August 18.A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers.
A Bakhshi, A Fanidi, Adam J. Bass, AG Letai, Aikou Okamoto, Alice Loo, AM Eder, Anil K. Rustgi, Anthony Letai, AS Lundberg, Azra H. Ligon, B Luo, BA Weir, Barbara A. Weir, Benjamin L. Ebert, C Scholl, C Spits, C Wu, Carmelo Nucera, Carter Hoffman, CG Mullighan, CG Mullighan, Craig H. Mermel, Cristina R. Antonescu, D Chitale, D Stuart, DA Barbie, Dale Porter, David G. Beer, Derek Y. Chiang, Derek Yecies, DG Albertson, DI Smith, Elizabeth Maher, Eric S. Lander, Francesca Demichelis, Frederic J. Kaye, G Tonon, Gad Getz, Guo Wei, Heidi Greulich, Hidefumi Sasaki, I Lahortiga, J Kendall, Jennifer Dobson, Jerry Donovan, Jesse S. Boehm, Joel E. Tepper, John Prensner, Jonathan A. Fletcher, Jordi Barretina, Josep Tabernero, José Baselga, JS Boehm, K Fukasawa, K Nishida, Kevin T. Mc Henry, Kumiko E. Tanaka, L Zender, LA Garraway, Lawrence D. True, Leila Haery, Levi A. Garraway, LJ Beverly, LT Smith, M Baudis, Marc Ladanyi, Mark A. Rubin, Mark J. Daly, Massimo Loda, Matthew Meyerson, Michael Reich, Michael S. Lawrence, Ming-Sound Tsao, Mitsuyoshi Urashima, ML Cleary, MR Stratton, N Lefort, N Rampino, P Dal Cin, P Hupé, P Zhou, PA Futreal, Pasi A. Janne, Qing Gao, R Beroukhim, R Mazzarella, R Wiedemeyer, Rameen Beroukhim, Reid M. Pinchback, RK Dearth, Ross L. Levine, S Myllykangas, S Raychaudhuri, Sabina Signoretti, Samuel Singer, Scott L. Pomeroy, Soumya Raychaudhuri, Stacey Gabriel, Ted Liefeld, Todd R. Golub, V Arena, Wendy Winckler, William R. Sellers, WM Lin, Y Tsujimoto, Yoon-Jae Cho   +106 more
core   +2 more sources

Aqua-vanadyl ion interaction with Nafion® membranes

Frontiers in Energy Research, 2015
Lack of comprehensive understanding about the interactions between Nafion membrane and battery electrolytes prevents the straightforward tailoring of optimal materials for redox flow battery applications.
Vijayakumar eMurugesan, Niranjan eGovind, Bin eLi, Xialiong eWei, Zimin eNie, Suntharampillai eThevuthasan, Vince eSprenkle, Wei eWang   +7 more
doaj   +1 more source

Permutation Entropy for Signal Analysis [PDF]

Discrete Mathematics & Theoretical Computer Science
Shannon Entropy is the preeminent tool for measuring the level of uncertainty (and conversely, information content) in a random variable. In the field of communications, entropy can be used to express the information content of given signals (represented
Bill Kay, Audun Myers, Thad Boydston, Emily Ellwein, Cameron Mackenzie, Iliana Alvarez, Erik Lentz   +6 more
doaj   +1 more source

The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes

Scientific Data, 2023
The OSU/PNNL Superfund Research Program (SRP) represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons (PAHs) at various superfund sites in the Pacific Northwest and assess their potential impact on human health.
Sara J. C. Gosline, Doo Nam Kim, Paritosh Pande, Dennis G. Thomas, Lisa Truong, Peter Hoffman, Michael Barton, Joseph Loftus, Addy Moran, Shawn Hampton, Scott Dowson, Lyndsey Franklin, David Degnan, Lindsey Anderson, Anne Thessen, Robyn L. Tanguay, Kim A. Anderson, Katrina M. Waters   +17 more
doaj   +1 more source

CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough

Frontiers in Microbiology, 2014
Geologic carbon dioxide (CO2) sequestration drives physical and geochemical changes in deep subsurface environments that impact indigenous microbial activities.
Michael J Wilkins, Michael J Wilkins, David W Hoyt, Matthew J Marshall, Paul A Alderson, Andrew E Plymale, L Meng Markilli, Abby E Tucker, Eric D Walter, Bryan E Linggi, Bryan E Linggi, Alice C Dohnalkova, Ron C Taylor   +12 more
doaj   +1 more source

Improving primary frequency response in networked microgrid operations using multilayer perceptron-driven reinforcement learning

IET Smart Grid, 2020
Individual microgrids can improve the reliability of power systems during extreme events, and networked microgrids can further improve efficiency through resource sharing and increase the resilience of critical end-use loads. However, networked microgrid
Nikitha Radhakrishnan, Indrasis Chakraborty, Indrasis Chakraborty, Jing Xie, Priya Thekkumparambath Mana, Francis K. Tuffner, Bishnu P. Bhattarai, Bishnu P. Bhattarai, Kevin P. Schneider   +8 more
doaj   +1 more source

How do North American weather regimes drive wind energy at the sub-seasonal to seasonal timescales?

npj Climate and Atmospheric Science, 2023
There has been an increasing need for forecasting power generation at the subseasonal to seasonal (S2S) timescales to support the operation, management, and planning of the wind-energy system.
Ye Liu, Sha Feng, Yun Qian, Huilin Huang, Larry K. Berg   +4 more
doaj   +1 more source

Pulses of enhanced North Pacific Intermediate Water ventilation from the Okhotsk Sea and Bering Sea during the last deglaciation [PDF]

, 2014
Under modern conditions only North Pacific Intermediate Water is formed in the Northwest Pacific Ocean. This situation might have changed in the past.
Kühn, H., Lembke-Jene, Lester, Mackensen, A., Max, L., Nürnberg, Dirk, Riethdorf, Jan-Rainer, Tiedemann, Ralf   +6 more
core   +2 more sources