Results 21 to 30 of about 1,369,975 (301)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Synthesising and utilising complex evidence to inform policy in education and health. [PDF]
, 2009 Oslo, Norway, May 19 to 21 ...
Pearson, M, Potts, H, Sheaff, R, Wong, G
core
Maktkontinuitet i munningen av Trondheimsfjorden
Heimen, 2017 The Trondheimsfjord runs from the Norwegian west coast far to the east, from where routes along the rivers lead to the Gulf of Bothnia. Continuity in power and prosperity at the mouth of the fiord is discussed, with the starting point in material ...
Birgitta Berglund, Thyra Solem
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Heimen, 2022 Fotografi kan være en kilde både til historie og til arkeologi, enten det er av bygninger som er revet, eller av endrete landskap. De kan være tatt for å dokumentere noe, eller de er tatt kun for å være personlige minner og uten intensjon om å være ...
Are Skarstein Kolberg
doaj +1 more source
Organic production in Norway [PDF]
, 2005 Present status of the Norwegian organic sector: -Official target of 10% organic production in 2010. -Organic production receives public subsidies -Marketing and production of plant products successful and growing -Marketing of livestock products ...
Wibe, Atle
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Falske nyheter, alternative fakta og sleipe knep
Heimen, 2018 From ca. 1870 to ca. 1900 mass meetings constituted a primary political arena in Norway, a place where political careers could be made and destroyed. National politics was exceedingly polarized during this period. In the years up to 1884, a heterogeneous
Nils Ivar Agøy
doaj +1 more source