Results 81 to 90 of about 2,486,691 (303)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Lectures on Diseases of the Nose and Throat. [PDF]

The American Journal of the Medical Sciences, 1887
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openaire   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

The electronic nose in respiratory medicine.

, 2013
Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry.
Montuschi, Paolo, Mores, Nadia
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

CATARRHAL DISEASES OF THE NOSE AND THROAT. [PDF]

JAMA: The Journal of the American Medical Association, 1896
To any careful observer, and all physicians should be such, it must have become apparent that catarrhal diseases of the nose and throat are becoming more and more frequent and play a most important part in the practice of every physician who gives more than passing attention to their treatment.
openaire   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Pattern of Ear, Nose and Throat Diseases in Addis Ababa

, 2022
Background: Estimate of Ear, Nose and Throat (ENT) diseases is not well documented in Ethiopia. This paper describes the pattern of ear, nose, and throat diseases among patients who attended the ENT unit at Tikur Anbessa Specialized Hospital, Addis Ababa,
Tolcha Kebebew, Assefa Tesfaye
core   +1 more source

Distribution of Sentinel Nodes in Non‐Parotid Salivary Gland Tumors—A Feasibility Study

Cancer Reports
Background Salivary gland carcinomas are rare and heterogeneous malignancies, more common in the parotid gland but also in submandibular and minor salivary glands. Surgery, often combined with radiotherapy, is the main treatment.
Marcus Jansson, Rusana Bark, Alexandra Elliot, Lalle Hammarstedt‐Nordenvall, Caroline Gahm   +4 more
doaj   +1 more source

Assessment of Olfactory Threshold in Patients Undergoing Radiotherapy for Head and Neck Malignancies [PDF]

Iranian Journal of Otorhinolaryngology, 2014
Introduction: Radiotherapy is a common treatment modality for patients with head and neck malignancies. As the nose lies within the field of radiotherapy of the head and neck, the olfactory fibers and olfactory receptors may be affected by radiation. The
Mir Mohammad Jalali, Hooshang Gerami, Abbas Rahimi, Manizheh Jafari   +3 more
doaj