Results 41 to 50 of about 336,762 (252)

Tunable n-path notch filters for blocker suppression: modeling and verification [PDF]

, 2013
N-path switched-RC circuits can realize filters with very high linearity and compression point while they are tunable by a clock frequency. In this paper, both differential and single-ended N-path notch filters are modeled and analyzed.
Ghaffari, A., Klumperink, E.A.M., Nauta, B.   +2 more
core   +2 more sources

Studies on surface effect and notch effect

Journal of Japan Institute of Light Metals, 1967
This paper reports the fatigue strength of welded aluminum alloys, mainly based on Al-Zn-Mg systems.The experiments were conducted on (1) The relation between the method of butt welding and the fatigue strength of parent alloys; (2) The comparison of stress concentration factors between the welds and parent alloys and the study on notch effect; (3) The
Yutaka ISHIKAWA, Susumu YOSHIDA
openaire   +2 more sources

Fatigue Probabilistic Approach of Notch Sensitivity of 51CrV4 Leaf Spring Steel Based on the Theory of Critical Distances

Applied Sciences
The mechanical and structural design of railway vehicles is heavily influenced by their lifetime. Because fatigue is a significant factor that impacts the longevity of railway components, it is imperative that the fatigue resistance properties of crucial
Vítor M. G. Gomes, Miguel A. V. de Figueiredo, José A. F. O. Correia, Abílio M. P. de Jesus   +3 more
doaj   +1 more source

AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster. [PDF]

PLoS Genetics, 2018
AKAP200 is a Drosophila melanogaster member of the "A Kinase Associated Protein" family of scaffolding proteins, known for their role in the spatial and temporal regulation of Protein Kinase A (PKA) in multiple signaling contexts. Here, we demonstrate an
Neeta Bala Tannan, Giovanna Collu, Ashley C Humphries, Ekatherina Serysheva, Ursula Weber, Marek Mlodzik   +5 more
doaj   +1 more source

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Frontiers in Cell and Developmental Biology, 2022
Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling.
Cansu Karakaya, Cansu Karakaya, Mark C. van Turnhout, Valery L. Visser, Tommaso Ristori, Tommaso Ristori, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Sandra Loerakker, Sandra Loerakker   +12 more
doaj   +1 more source

Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]

, 2008
We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis, Davidson, Dawson, E. H. Davidson, Fisher, Giagtzoglou, Gyory, Howard-Ashby, Howard-Ashby, J. Smith, Kuo, Lee, Livi, Materna, McClay, Minokawa, Oellers, Oliveri, Osipovich, Peterson, Ransick, Revilla-i-Domingo, Rizzo, Robertson, Sea Urchin Genome Sequencing Consortium, Sherwood, Smith, Smith, Thirunavukkarasu, Tietze, Tu, Walton, Wikramanayake, Yu, Yuh   +34 more
core   +3 more sources

Cis-interactions between Notch and its ligands block ligand-independent Notch activity

eLife, 2014
The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate
William Hunt Palmer, Dongyu Jia, Wu-Min Deng   +2 more
doaj   +1 more source

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +3 more sources

Design Optimization and Experimental Study of CFRP Plate Anchorage with Clip-Extension Type

Zhongwai Gonglu
Existing anchorage is prone to damaging the carbon-fiber reinforced polymer (CFRP) plate due to the “notch effect” and uneven distribution of clamping stress. This study proposed a new clip-extension type anchorage for the CFRP plate.
QI Yijia, XIAO Dan, WANG Zhongqiang
doaj   +1 more source